A novel RUNX1 mutation with ANKRD26 dysregulation is related to thrombocytopenia in a sporadic form of myelodysplastic syndrome

• Published in: Aging clinical and experimental research Vol. 33; no. 7; pp. 1987 - 1992
• Main Authors: Ferrari, Silvia, Regazzo, Daniela, Omenetto, Elisabetta, Scaroni, Carla, Semenzato, Gianpietro, Fabris, Fabrizio, Vianello, Fabrizio
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.07.2021; Springer Nature B.V
• Subjects: Anemia; Core Binding Factor Alpha 2 Subunit - genetics; Erythrocytes; Genetic Predisposition to Disease; Geriatrics/Gerontology; Humans; Intercellular Signaling Peptides and Proteins; Leukemia; Medicine; Medicine & Public Health; Mutation; Myelodysplastic Syndromes; Short Communication; Thrombocytopenia; Thrombocytopenia; Platelets; Myelodysplastic syndromes; ANKRD26; RUNX1

Aging is associated with a higher risk of developing malignant diseases, including myelodysplastic syndromes, clonal disorders characterised by chronic cytopenias (anaemia, neutropenia and thrombocytopenia) and abnormal cellular maturation. Myelodysplastic syndromes arising in older subjects are inf...