PTEN loss activates a functional AKT/CXCR4 signaling axis to potentiate tumor growth and lung metastasis in human osteosarcoma cells

• Published in: Clinical & experimental metastasis Vol. 37; no. 1; pp. 173 - 185
• Main Authors: Xi, Yongming, Qi, Zonghua, Ma, Jinfeng, Chen, Yan
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.02.2020; Springer Nature B.V
• Subjects: Activation; Adolescents; AKT protein; Animals; Anticancer properties; Antitumor activity; Biomedical and Life Sciences; Biomedical materials; Biomedicine; Bone and Bones - pathology; Bone cancer; Bone growth; Bone loss; Bone Neoplasms - drug therapy; Bone Neoplasms - pathology; Bone tumors; Cancer Research; Cell Line, Tumor; Chemokines; Children; Crosstalk; CXCR4 protein; Down-Regulation; Extracellular signal-regulated kinase; Gene Knockdown Techniques; Hematology; Heterocyclic Compounds - pharmacology; Heterocyclic Compounds - therapeutic use; Humans; In vivo methods and tests; Kinases; Lung - pathology; Lung cancer; Lung Neoplasms - drug therapy; Lung Neoplasms - secondary; Lungs; Male; Metastases; Metastasis; Mice; Oncology; Osteosarcoma; Osteosarcoma - drug therapy; Osteosarcoma - secondary; Osteosarcoma cells; Proto-Oncogene Proteins c-akt - metabolism; PTEN Phosphohydrolase - genetics; PTEN Phosphohydrolase - metabolism; PTEN protein; Receptors, CXCR4 - antagonists & inhibitors; Receptors, CXCR4 - metabolism; Research Paper; Restoration; RNA, Small Interfering - metabolism; Sarcoma; Signal Transduction - drug effects; Signal Transduction - genetics; Signaling; Surgical Oncology; Tumor suppressor genes; Tumors; Xenograft Model Antitumor Assays; PTEN; CXCR4; AKT; Lung metastasis; Osteosarcoma; ERK

Osteosarcoma (OS) is the most common primary malignant bone tumor in children and adolescents. Loss of the tumor suppressor PTEN or activation of chemokine receptor CXCR4 has been demonstrated to associate with OS respectively. However, the signaling mechanism underlying PTEN-mediated antitumor effe...