The association of testis‐specific hTAF7L gene variants with idiopathic azoospermic and severe oligozoospermic male infertility

• Published in: Andrologia Vol. 54; no. 11; pp. e14581 - n/a
• Main Authors: Ambulkar, Prafulla S., Waghmare, Jwalant E., Verma Shivkumar, Poonam, Chaudhari, Ajay R., Gangane, Nitin M., Narang, Pratibha, Pal, Asoke K.
• Format: Journal Article
• Language: English
• Published: Berlin John Wiley & Sons, Inc 01.12.2022
• Subjects: Exons; Gene expression; hTAF7L gene; idiopathic male infertility; Infertility; Males; missense variants; Oligozoospermia; Single-nucleotide polymorphism; Spermatogenesis; Statistical analysis; TATA-binding protein; X‐chromosome

Spermatogenesis is regulated by complex tissue specific gene expression in the testis to achieve normal male fertility. X‐chromosome specific TATA binding protein (TBP)‐associated factor 7L (hTAF7L) is one of the transcriptional regulator genes considered essential for spermatogenesis. The aim of th...