Anti-Aβ-scFv-loaded polymeric nano-micelles with enhanced plasma stability

• Published in: Journal of pharmacy and pharmacology Vol. 73; no. 4; p. 460
• Main Authors: Sotoudegan, Farnaz, Sotoudegan, Farzaneh, Talebkhan Garoosi, Yeganeh, Afshar, Sahar H, Barkhordari, Farzaneh, Davami, Fatemeh
• Format: Journal Article
• Language: English
• Published: England 08.03.2021
• Subjects: Anti-amyloid-beta; Pluronics; SCFV; polymeric nano-micelles; immunotherapy

Immunotherapy using recombinant monoclonal antibodies specifically Anti-amyloid-beta (Anti-Aβ) scFv is envisaged as an appropriate therapeutic for Alzheimer through reduction of amyloid-beta aggregation. The solubilization of therapeutics using polymeric micelles facilitates an improved bioavailabil...