Effect of aberrant DNA methylation on cancer stem cell properties
DNA methylation, as an epigenetic mechanism, occurs by adding a methyl group of cytosines in position 5 by DNA methyltransferases and has essential roles in cellular function, especially in the transcriptional regulation of embryonic and adult stem cells. Hypomethylation and hypermethylation cause e...
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| Published in | Experimental and molecular pathology Vol. 125; p. 104757 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier Inc
01.04.2022
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0014-4800 1096-0945 1096-0945 |
| DOI | 10.1016/j.yexmp.2022.104757 |
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| Abstract | DNA methylation, as an epigenetic mechanism, occurs by adding a methyl group of cytosines in position 5 by DNA methyltransferases and has essential roles in cellular function, especially in the transcriptional regulation of embryonic and adult stem cells. Hypomethylation and hypermethylation cause either the expression or inhibition of genes, and there is a tight balance between regulating the activation or repression of genes in normal cellular activity. Abnormal methylation is well-known hallmark of cancer development and progression and can switch normal stem cells into cancer stem cells. Cancer Stem Cells (CSCs) are minor populations of tumor cells that exhibit unique properties such as self-regeneration, resistance to chemotherapy, and high ability of metastasis. The purpose of this paper is to show how aberrant DNA methylation accumulation affects self-renewal, differentiation, multidrug-resistant, and metastasis processes in cancer stem cells.
DNA methylation controls stem cell fate, and aberrant methylation induces CSCs formation that has a role in self-regenerate, metastasis, and drug resistance. [Display omitted]
•Abnormal methylation creates cancer stem cells.•Aberrant methylation has a role in self re-newel of cancer stem cells.•Abnormal methylation is responsible for drug-resistance in cancer stem cells.•Alterations in normal methylation patterns induces metastasis of cancer stem cells. |
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| AbstractList | DNA methylation, as an epigenetic mechanism, occurs by adding a methyl group of cytosines in position 5 by DNA methyltransferases and has essential roles in cellular function, especially in the transcriptional regulation of embryonic and adult stem cells. Hypomethylation and hypermethylation cause either the expression or inhibition of genes, and there is a tight balance between regulating the activation or repression of genes in normal cellular activity. Abnormal methylation is well-known hallmark of cancer development and progression and can switch normal stem cells into cancer stem cells. Cancer Stem Cells (CSCs) are minor populations of tumor cells that exhibit unique properties such as self-regeneration, resistance to chemotherapy, and high ability of metastasis. The purpose of this paper is to show how aberrant DNA methylation accumulation affects self-renewal, differentiation, multidrug-resistant, and metastasis processes in cancer stem cells.DNA methylation, as an epigenetic mechanism, occurs by adding a methyl group of cytosines in position 5 by DNA methyltransferases and has essential roles in cellular function, especially in the transcriptional regulation of embryonic and adult stem cells. Hypomethylation and hypermethylation cause either the expression or inhibition of genes, and there is a tight balance between regulating the activation or repression of genes in normal cellular activity. Abnormal methylation is well-known hallmark of cancer development and progression and can switch normal stem cells into cancer stem cells. Cancer Stem Cells (CSCs) are minor populations of tumor cells that exhibit unique properties such as self-regeneration, resistance to chemotherapy, and high ability of metastasis. The purpose of this paper is to show how aberrant DNA methylation accumulation affects self-renewal, differentiation, multidrug-resistant, and metastasis processes in cancer stem cells. DNA methylation, as an epigenetic mechanism, occurs by adding a methyl group of cytosines in position 5 by DNA methyltransferases and has essential roles in cellular function, especially in the transcriptional regulation of embryonic and adult stem cells. Hypomethylation and hypermethylation cause either the expression or inhibition of genes, and there is a tight balance between regulating the activation or repression of genes in normal cellular activity. Abnormal methylation is well-known hallmark of cancer development and progression and can switch normal stem cells into cancer stem cells. Cancer Stem Cells (CSCs) are minor populations of tumor cells that exhibit unique properties such as self-regeneration, resistance to chemotherapy, and high ability of metastasis. The purpose of this paper is to show how aberrant DNA methylation accumulation affects self-renewal, differentiation, multidrug-resistant, and metastasis processes in cancer stem cells. DNA methylation controls stem cell fate, and aberrant methylation induces CSCs formation that has a role in self-regenerate, metastasis, and drug resistance. [Display omitted] •Abnormal methylation creates cancer stem cells.•Aberrant methylation has a role in self re-newel of cancer stem cells.•Abnormal methylation is responsible for drug-resistance in cancer stem cells.•Alterations in normal methylation patterns induces metastasis of cancer stem cells. DNA methylation, as an epigenetic mechanism, occurs by adding a methyl group of cytosines in position 5 by DNA methyltransferases and has essential roles in cellular function, especially in the transcriptional regulation of embryonic and adult stem cells. Hypomethylation and hypermethylation cause either the expression or inhibition of genes, and there is a tight balance between regulating the activation or repression of genes in normal cellular activity. Abnormal methylation is well-known hallmark of cancer development and progression and can switch normal stem cells into cancer stem cells. Cancer Stem Cells (CSCs) are minor populations of tumor cells that exhibit unique properties such as self-regeneration, resistance to chemotherapy, and high ability of metastasis. The purpose of this paper is to show how aberrant DNA methylation accumulation affects self-renewal, differentiation, multidrug-resistant, and metastasis processes in cancer stem cells. |
| ArticleNumber | 104757 |
| Author | Movassaghpour, Ali Akbar Mazloumi, Zeinab Karimipour, Mohammad Montazer, Majid Rafat, Ali Nozad Charoudeh, Hojjatollah Farahzadi, Raheleh Dehnad, Alireza Dizaji Asl, Khadijeh |
| Author_xml | – sequence: 1 givenname: Zeinab surname: Mazloumi fullname: Mazloumi, Zeinab organization: Department of Applied Cell Sciences, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran – sequence: 2 givenname: Raheleh surname: Farahzadi fullname: Farahzadi, Raheleh organization: Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran – sequence: 3 givenname: Ali surname: Rafat fullname: Rafat, Ali organization: Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran – sequence: 4 givenname: Khadijeh surname: Dizaji Asl fullname: Dizaji Asl, Khadijeh organization: Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran – sequence: 5 givenname: Mohammad surname: Karimipour fullname: Karimipour, Mohammad organization: Department of Anatomical Sciences, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran – sequence: 6 givenname: Majid surname: Montazer fullname: Montazer, Majid organization: Department of Cardiovascular Surgery, Imam Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran – sequence: 7 givenname: Ali Akbar surname: Movassaghpour fullname: Movassaghpour, Ali Akbar organization: Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran – sequence: 8 givenname: Alireza surname: Dehnad fullname: Dehnad, Alireza organization: Department of Bacterial Disease Research, Razi Vaccine and Serum Research Institute, AREEO, Tabriz, Iran – sequence: 9 givenname: Hojjatollah surname: Nozad Charoudeh fullname: Nozad Charoudeh, Hojjatollah email: nozadh@tbzmed.ac.ir organization: Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35339454$$D View this record in MEDLINE/PubMed |
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| Keywords | HH DNMT1,2,3A,3B,3 L HHIP PTEN DMRs Metastasis SPINT2 Drug resistance ETS1 MBD1, 2, 3 MECP2 YY1 Oct4 Sox2 PBD IGFBP-3 CDH1 HSC CSCs AML CARD10 TRAIL DKK DAPK Notch PTPN HCC AXIN2 ZBTB33 EMT RUNX3 ES CCNA1 CGIs MMR ZEB1 Smo WIF SAM Fas-L pre-LSCs PCNA UHRF1 GSTP1 APAF-1 PTCH ASCL2 BCSC TWIST Self-renewal MDR1 ALDHs GBM GSC PENK DNA methylation cancer stem cells Wnt MGMT HMGA1 TGF-B Nanog 5mC MLH1 CH3 LSCs SFRP SNAI1 mESC LGR5 |
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| SubjectTerms | Adult cancer stem cells DNA methylation DNA Methylation - genetics Drug resistance Epigenesis, Genetic Gene Expression Regulation, Neoplastic Humans Metastasis Neoplasms - pathology Neoplastic Stem Cells - pathology Self-renewal |
| Title | Effect of aberrant DNA methylation on cancer stem cell properties |
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