Pharmacogenetics in transplant patients: can it predict pharmacokinetics and pharmacodynamics?

• Published in: Therapeutic drug monitoring Vol. 28; no. 1; p. 23
• Main Authors: Burckart, Gilbert J, Liu, Xiaomei I
• Format: Journal Article
• Language: English
• Published: United States 01.02.2006
• Subjects: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters - genetics; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System - genetics; Humans; Immunosuppressive Agents - pharmacokinetics; Immunosuppressive Agents - pharmacology; Immunosuppressive Agents - therapeutic use; Mice; Organ Transplantation; Pharmacogenetics - methods; Pharmacogenetics - trends; Polymorphism, Genetic; Predictive Value of Tests

Pharmacogenetics holds the potential to allow individualized dosing of immunosuppressive agents to optimize their therapeutic effect while minimizing adverse effects. As more pharmacogenetic information accumulates, the prospect of reducing or discontinuing the intensive therapeutic drug monitoring...