Synthetic and editing mechanisms of aminoacyl-tRNA synthetases

• Published in: Topics in current chemistry Vol. 344; p. 1
• Main Authors: Perona, John J, Gruic-Sovulj, Ita
• Format: Journal Article
• Language: English
• Published: Germany 01.01.2014
• Subjects: Amino Acyl-tRNA Synthetases - chemistry; Amino Acyl-tRNA Synthetases - metabolism; Animals; Humans; RNA Editing; RNA, Transfer, Amino Acyl - biosynthesis; RNA, Transfer, Amino Acyl - metabolism

Aminoacyl-tRNA synthetases (aaRS) ensure the faithful transmission of genetic information in all living cells. The 24 known aaRS families are divided into 2 structurally distinct classes (class I and class II), each featuring a catalytic domain with a common fold that binds ATP, amino acid, and the...