Differential metabolism of dihomo-gamma-linolenic acid and arachidonic acid by cyclo-oxygenase-1 and cyclo-oxygenase-2: implications for cellular synthesis of prostaglandin E1 and prostaglandin E2

• Published in: Biochemical journal Vol. 365; no. Pt 2; pp. 489 - 496
• Main Authors: Levin, Galit, Duffin, Kevin L, Obukowicz, Mark G, Hummert, Susan L, Fujiwara, Hideji, Needleman, Philip, Raz, Amiram
• Format: Journal Article
• Language: English
• Published: England 15.07.2002
• Subjects: 8,11,14-Eicosatrienoic Acid - metabolism; Alprostadil - biosynthesis; Animals; Arachidonic Acid - metabolism; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone - biosynthesis; Isoenzymes - metabolism; Kinetics; Membrane Proteins; Mice; Prostaglandin-Endoperoxide Synthases - metabolism; Recombinant Proteins - metabolism; Tumor Cells, Cultured

Prostaglandin (PG) E(1) has been shown to possess anti-inflammatory properties and to modulate vascular reactivity. These activities are sometimes distinct from those of PGE(2), suggesting that endogenously produced PGE(1) may have some beneficial therapeutic effects compared with PGE(2). Increasing...