One‐pot Construction of Dibenzooxabicyclo[5.5.0]dodecanes

• Published in: Advanced synthesis & catalysis Vol. 364; no. 23; pp. 4110 - 4121
• Main Authors: Hsueh, Nai‐Chen, Chen, Kuan‐Ting, Chang, Meng‐Yang
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 08.12.2022
• Subjects: Alkylation; Annulation; Chemistry; Chemistry, Applied; Chemistry, Organic; Nucleophilic substitution; One-pot reaction; Physical Sciences; Polycycles; Science & Technology; Nucleophilic substitution; Annulation; Alkylation; One-pot reaction; Polycycles

Under the open‐vessel atmosphere conditions, the one‐pot synthesis of bis‐sulfonyl dibenzooxabicyclo[5.5.0]dodecanes was developed by double substitution of 1,3‐dichloroacetone with arenesulfinic acid sodium salts, and C‐ and O‐alkylation of the resulting 1,3‐bis‐sulfonylacetones with 2 equivalents...