A Study on the Crystal Transformation Relationships of Valacyclovir Hydrochloride Polymorphs: Sesquihydrate, Form I, and Form II
Valacyclovir hydrochloride is a kind of antiviral drug and has several crystal forms including sesquihydrate (SH), anhydrous Form I, and Form II. Here, the dehydration process of SH by heat drying is investigated by powder X‐ray diffraction, differential scanning calorimetry, thermogravimetry analys...
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| Published in | Crystal research and technology (1979) Vol. 56; no. 12 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
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01.12.2021
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| Abstract | Valacyclovir hydrochloride is a kind of antiviral drug and has several crystal forms including sesquihydrate (SH), anhydrous Form I, and Form II. Here, the dehydration process of SH by heat drying is investigated by powder X‐ray diffraction, differential scanning calorimetry, thermogravimetry analysis, vapor sorption analysis, and ReactRaman spectroscopy, and the dehydration and absorption of crystal water are revealed. The transformations of SH to Form I, Form II to Form I, and SH to Form II in aqueous ethanol suspension are monitored by ReactRaman spectroscopy, and the mechanisms of two different transition processes are defined through the analysis of ReactRaman spectra. The crystal transformation relationship of the mentioned forms is established.
Valacyclovir hydrochloride is an antiviral drug and has several crystal forms. The dehydration process of sesquihydrate by heating is investigated. Transformations of sesquihydrate to Form I, Form II to Form I, and sesquihydrate to Form II in aqueous ethanol suspension are monitored by ReactRaman spectroscopy. The mechanisms of different transition processes are defined through the analysis of Raman spectra. |
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| AbstractList | Valacyclovir hydrochloride is a kind of antiviral drug and has several crystal forms including sesquihydrate (SH), anhydrous Form I, and Form II. Here, the dehydration process of SH by heat drying is investigated by powder X‐ray diffraction, differential scanning calorimetry, thermogravimetry analysis, vapor sorption analysis, and ReactRaman spectroscopy, and the dehydration and absorption of crystal water are revealed. The transformations of SH to Form I, Form II to Form I, and SH to Form II in aqueous ethanol suspension are monitored by ReactRaman spectroscopy, and the mechanisms of two different transition processes are defined through the analysis of ReactRaman spectra. The crystal transformation relationship of the mentioned forms is established. Valacyclovir hydrochloride is a kind of antiviral drug and has several crystal forms including sesquihydrate (SH), anhydrous Form I, and Form II. Here, the dehydration process of SH by heat drying is investigated by powder X‐ray diffraction, differential scanning calorimetry, thermogravimetry analysis, vapor sorption analysis, and ReactRaman spectroscopy, and the dehydration and absorption of crystal water are revealed. The transformations of SH to Form I, Form II to Form I, and SH to Form II in aqueous ethanol suspension are monitored by ReactRaman spectroscopy, and the mechanisms of two different transition processes are defined through the analysis of ReactRaman spectra. The crystal transformation relationship of the mentioned forms is established. Valacyclovir hydrochloride is an antiviral drug and has several crystal forms. The dehydration process of sesquihydrate by heating is investigated. Transformations of sesquihydrate to Form I, Form II to Form I, and sesquihydrate to Form II in aqueous ethanol suspension are monitored by ReactRaman spectroscopy. The mechanisms of different transition processes are defined through the analysis of Raman spectra. |
| Author | Wang, Nai‐Xing Liu, Yan Zhang, Hao Chen, Tian Wu, Yan‐Fang |
| Author_xml | – sequence: 1 givenname: Yan‐Fang surname: Wu fullname: Wu, Yan‐Fang organization: East China University of Science and Technology – sequence: 2 givenname: Hao surname: Zhang fullname: Zhang, Hao organization: East China University of Science and Technology – sequence: 3 givenname: Nai‐Xing surname: Wang fullname: Wang, Nai‐Xing organization: Zhejiang Charioteer Pharmaceutical Co., Ltd – sequence: 4 givenname: Tian surname: Chen fullname: Chen, Tian organization: Zhejiang Charioteer Pharmaceutical Co., Ltd – sequence: 5 givenname: Yan orcidid: 0000-0002-2528-472X surname: Liu fullname: Liu, Yan email: liuyancrystal@ecust.edu.cn organization: East China University of Science and Technology |
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| Snippet | Valacyclovir hydrochloride is a kind of antiviral drug and has several crystal forms including sesquihydrate (SH), anhydrous Form I, and Form II. Here, the... |
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| Title | A Study on the Crystal Transformation Relationships of Valacyclovir Hydrochloride Polymorphs: Sesquihydrate, Form I, and Form II |
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