Signal Transduction in Receptor for Advanced Glycation End Products (RAGE)

• Published in: The Journal of biological chemistry Vol. 287; no. 7; pp. 5133 - 5144
• Main Authors: Rai, Vivek, Maldonado, Andres Y., Burz, David S., Reverdatto, Sergey, Schmidt, Ann Marie, Shekhtman, Alexander
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.02.2012
• Subjects: Diabetes; NMR; Receptor for Advanced Glycation End Products (RAGE); Receptor Structure-Function; Signal Transduction; Receptor for Advanced Glycation End Products (RAGE); NMR; Receptor Structure-Function; Diabetes; Signal Transduction

The receptor for advanced glycation end products (RAGE) is a multiligand cell surface macromolecule that plays a central role in the etiology of diabetes complications, inflammation, and neurodegeneration. The cytoplasmic domain of RAGE (C-terminal RAGE; ctRAGE) is critical for RAGE-dependent signal...