Gene expression during terminal differentiation: dexamethasone suppression of inducer-mediated alpha 1- and beta maj-globin gene expression

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 82; no. 15; pp. 5020 - 5024
• Main Authors: Kaneda, T, Murate, T, Sheffery, M, Brown, K, Rifkind, R A, Marks, P A
• Format: Journal Article
• Language: English
• Published: United States National Acad Sciences 01.08.1985
• Subjects: Acetamides - antagonists & inhibitors; Animals; Cell Differentiation - drug effects; Cell Division - drug effects; Cell Line; Chromatin - physiology; Chromatin - ultrastructure; Dexamethasone - pharmacology; Gene Expression Regulation - drug effects; Globins - genetics; Leukemia, Erythroblastic, Acute - pathology; Mice; Transcription, Genetic - drug effects

Previous studies demonstrated that hexamethylenebisacetamide (HMBA)-mediated murine erythroleukemia cell (MELC) commitment to terminal division could be suppressed by dexamethasone. A rapid (less than 2 hr) increase (step-up) in commitment to terminal cell division was observed if, after 60-70 hr in...