Expression of transforming growth factor beta 2 RNA during murine embryogenesis

We have studied the temporal and spatial expression of transforming growth factor beta 2 (TGF beta 2) RNA in mouse embryos from 10.5 days post coitum (p.c.) to 3 days post partum (p.p.) by in situ hybridization analysis. TGF beta 2 RNA is expressed in a variety of tissues including bone, cartilage,...

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Bibliographic Details
Published inDevelopment (Cambridge) Vol. 106; no. 4; pp. 759 - 767
Main Authors Pelton, R W, Nomura, S, Moses, H L, Hogan, B L
Format Journal Article
LanguageEnglish
Published England The Company of Biologists Limited 01.08.1989
Subjects
Animals
Embryo, Mammalian - cytology
Embryo, Mammalian - physiology
Embryonic and Fetal Development
Female
Gestational Age
In Situ Hybridization
Male
Mice
Mice, Inbred ICR
Mice, Inbred Strains
Organ Specificity
RNA - analysis
RNA - metabolism
Transforming Growth Factor beta - biosynthesis
Transforming Growth Factor beta - genetics
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Summary:We have studied the temporal and spatial expression of transforming growth factor beta 2 (TGF beta 2) RNA in mouse embryos from 10.5 days post coitum (p.c.) to 3 days post partum (p.p.) by in situ hybridization analysis. TGF beta 2 RNA is expressed in a variety of tissues including bone, cartilage, tendon, gut, blood vessels, skin and fetal placenta, and is in general found in the mesenchymal component of these tissues. The expression of TGF beta 2 RNA changes during development in a manner consistent with a role for the gene product in mediating mesenchymal-epithelial interactions.
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ISSN:0950-1991
1477-9129
DOI:10.1242/dev.106.4.759