Mendelian randomization and multi-omics approach analyses reveal impaired glucose metabolism and oxidative phosphorylation in visceral adipose tissue of women with polycystic ovary syndrome

• Published in: Human reproduction (Oxford) Vol. 39; no. 12; pp. 2785 - 2797
• Main Authors: Zhang, Yurong, Jiang, Xintong, Song, Xueling, Zhang, Jiajia, Mao, Weian, Chen, Wei, Yuan, Shuai, Chen, Yijie, Mu, Liangshan, Zhao, Yue
• Format: Journal Article
• Language: English
• Published: England 01.12.2024
• Subjects: Adult; Female; Glucose - metabolism; Humans; Intra-Abdominal Fat - metabolism; Mendelian Randomization Analysis; Metabolomics - methods; Multiomics; Oxidative Phosphorylation; Polycystic Ovary Syndrome - genetics; Polycystic Ovary Syndrome - metabolism; Proteomics - methods; Young Adult; Mendelian randomization; glucose metabolism; oxidative phosphorylation; polycystic ovary syndrome; visceral adipose tissue
• ISSN: 0268-1161; 1460-2350; 1460-2350
• DOI: 10.1093/humrep/deae244

What is the significance of visceral adipose tissue (VAT) in the pathogenesis of polycystic ovary syndrome (PCOS) and its impact on the regulation of metabolic disorders in women with PCOS? We revealed a potentially causal relationship between increased genetically predicted VAT and PCOS-related tra...