Diesters on the basis of 16-hydroxyisosteviol and dicarboxylic acids as carriers of Fe(III) picrates

Diesters on the basis of 16-hydroxyisosteviol and dicarboxylic acids, exhibiting anti-tubercular activity, transport Fe(III) through liquid chloroform membrane which models a cell membrane. It is revealed that fluxes and anti-tubercular activity increase, as the length of the chain (spacer) between...

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Published inJournal of Inclusion Phenomena and Macrocyclic Chemistry Vol. 60; no. 1-2; pp. 51 - 58
Main Authors Kataev, Vladimir E., Militsina, Olesya I., Strobykina, Irina Yu, Gubaidullin, Aidar T., Zverev, Vladislav V., Kataeva, Olga N., Fedorova, Olga V., Valova, Marina S., Rusinov, Gennadiy L.
Format Journal Article
LanguageEnglish
Published Dordrecht Springer Netherlands 01.02.2008
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Abstract Diesters on the basis of 16-hydroxyisosteviol and dicarboxylic acids, exhibiting anti-tubercular activity, transport Fe(III) through liquid chloroform membrane which models a cell membrane. It is revealed that fluxes and anti-tubercular activity increase, as the length of the chain (spacer) between two ent -beyran skeletons of diesters increases. Computations on the level DFT/PBE explain the dependence of complexes stability on a structure of diterpenoid ligands. The structures of three diesters were established by single crystal X-ray analysis.
AbstractList Diesters on the basis of 16-hydroxyisosteviol and dicarboxylic acids, exhibiting anti-tubercular activity, transport Fe(III) through liquid chloroform membrane which models a cell membrane. It is revealed that fluxes and anti-tubercular activity increase, as the length of the chain (spacer) between two ent -beyran skeletons of diesters increases. Computations on the level DFT/PBE explain the dependence of complexes stability on a structure of diterpenoid ligands. The structures of three diesters were established by single crystal X-ray analysis.
Author Gubaidullin, Aidar T.
Zverev, Vladislav V.
Strobykina, Irina Yu
Valova, Marina S.
Kataev, Vladimir E.
Kataeva, Olga N.
Militsina, Olesya I.
Fedorova, Olga V.
Rusinov, Gennadiy L.
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  fullname: Rusinov, Gennadiy L.
  organization: Institute of Organic Synthesis UrB RAS
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Issue 1-2
Keywords Siderophores
Diterpenoids
Isosteviol
Beyerans
Anti-tubercular activity
Transport of Fe(III)
Language English
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PublicationTitle Journal of Inclusion Phenomena and Macrocyclic Chemistry
PublicationTitleAbbrev J Incl Phenom Macrocycl Chem
PublicationYear 2008
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Snippet Diesters on the basis of 16-hydroxyisosteviol and dicarboxylic acids, exhibiting anti-tubercular activity, transport Fe(III) through liquid chloroform membrane...
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SubjectTerms Chemistry
Chemistry and Materials Science
Crystallography and Scattering Methods
Food Science
Organic Chemistry
Original Article
Title Diesters on the basis of 16-hydroxyisosteviol and dicarboxylic acids as carriers of Fe(III) picrates
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