Part 3: Enhanced Approaches to the Development of the Control Strategy and its Implementation in the Manufacturing Process Description
A series of case histories from IQ consortium member companies will be presented to exemplify how the application of the ICH Q11 vision for enhanced Quality by Design (QbD) development of the active pharmaceutical ingredient (API) can lead to differentiated outcomes for elements such as the API supp...
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| Published in | Journal of pharmaceutical innovation Vol. 14; no. 1; pp. 1 - 14 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York
Springer US
15.03.2019
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| Subjects | |
| Online Access | Get full text |
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| Abstract | A series of case histories from IQ consortium member companies will be presented to exemplify how the application of the ICH Q11 vision for enhanced Quality by Design (QbD) development of the active pharmaceutical ingredient (API) can lead to differentiated outcomes for elements such as the API supply chain and control strategy, and how changes to such outcomes are managed over the lifecycle. A series of articles will address “flexibility” and look to provide recommendations for the further development of the ICH Q11 vision. The focus of this work will address flexibility associated with the “Enhanced Approaches to the Development of the Control Strategy and Its Implementation in the Manufacturing Process Description.” |
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| AbstractList | A series of case histories from IQ consortium member companies will be presented to exemplify how the application of the ICH Q11 vision for enhanced Quality by Design (QbD) development of the active pharmaceutical ingredient (API) can lead to differentiated outcomes for elements such as the API supply chain and control strategy, and how changes to such outcomes are managed over the lifecycle. A series of articles will address “flexibility” and look to provide recommendations for the further development of the ICH Q11 vision. The focus of this work will address flexibility associated with the “Enhanced Approaches to the Development of the Control Strategy and Its Implementation in the Manufacturing Process Description.” |
| Author | Luciani, Carla V. Popkin, Matt E. Srivastava, Sushil Lepore, John V. Hobson, Lindsay Seibert, Kevin D. Omer, Batool Ahmed |
| Author_xml | – sequence: 1 givenname: Matt E. surname: Popkin fullname: Popkin, Matt E. email: matt.e.popkin@gsk.com organization: Product Development and Supply, GlaxoSmithKline Ltd – sequence: 2 givenname: Batool Ahmed surname: Omer fullname: Omer, Batool Ahmed organization: Product Development and Supply, GlaxoSmithKline Ltd – sequence: 3 givenname: Kevin D. surname: Seibert fullname: Seibert, Kevin D. organization: Small Molecule Design and Development, Eli Lilly and Co., Lilly Technology Center – sequence: 4 givenname: Carla V. surname: Luciani fullname: Luciani, Carla V. organization: Small Molecule Design and Development, Eli Lilly and Co., Lilly Technology Center – sequence: 5 givenname: Sushil surname: Srivastava fullname: Srivastava, Sushil organization: Chemical Development, Bristol-Myers Squibb Company – sequence: 6 givenname: Lindsay surname: Hobson fullname: Hobson, Lindsay organization: Chemical Development, Bristol-Myers Squibb Company – sequence: 7 givenname: John V. surname: Lepore fullname: Lepore, John V. organization: Chemical Process Development and Commercialization, Merck |
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| Cites_doi | 10.1021/acs.oprd.5b00158 10.1021/acs.oprd.6b00073 10.1021/op058014i 10.1021/op200362h 10.1021/op5003177 10.1021/ie071256h 10.1021/op9901801 10.1021/op4001127 10.1021/acs.oprd.6b00253 10.1021/op0100605 10.1021/op050133a 10.1021/acs.oprd.5b00146 10.1021/op3002646 10.1021/op500204z 10.1007/s12247-008-9028-0 |
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| Keywords | Design space Manufacturing process description S2.2 CMC Design of experiment (DoE) Process Models Kinetics Control strategy Methods ICH Quality by design (QbD) |
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| PublicationTitle | Journal of pharmaceutical innovation |
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| References | Am EndeDCliffordPDeAntonisDSantamariaCBrenekSPreparation of grignard reactants: ftir and calorimetric investigation for safe scale upOrg. Proc. Res. Dev1999331932910.1021/op99018011:CAS:528:DyaK1MXktl2hsrY%3D PolsterCColeKBurchamCCampbellBFrederickAHansenMHardingMHellerMMillerMPhillipsJPollockPZaborenkoNPilot-scale continuous production of LY2888721: amide formation and reactive crystallizationOrg Proc Res Dev2014181295130910.1021/op500204z1:CAS:528:DC%2BC2cXhslChtr7E García-MuñozSLucianiCVaidyaramanSSeibertKDefinition of design spaces using mechanistic models and geometric projections of probability mapsOrg. Proc. Res. Dev.2015191012102310.1021/acs.oprd.5b001581:CAS:528:DC%2BC2MXhtFOlsLrE ThomsonNSingerRSeibertKLucianiCSrivastavaSKiesmanWIrdamELeporeJSchenckLCase studies in development of drug substance control strategyOrg. Proc. Res. Dev.20151993594810.1021/acs.oprd.5b001461:CAS:528:DC%2BC2MXpsFaksbg%3D HoekstraLVonkPHulshofLModeling the scale-up of contact drying processesOrg. Proc. Res. Dev.200610340941610.1021/op058014i1:CAS:528:DC%2BD28XjslKnsb4%3D RathoreAVelayudhanAGuidelines for optimization and scale-up in preparative chromatographyBioPharm International20031634421:CAS:528:DC%2BD3sXht1yltr8%3D The development of a control strategy for a final intermediate towards the preparation of a drug substance is described in Org. Process Res.Dev.2016, 20, 1781–1791 (published on October 7, 2016). SeibertKSethuramanSMitchellJGriffithsKMcGarveyBThe use of routine process capability for the determination of process parameter criticality in small-molecule API synthesis: JPharm Innov2008310511210.1007/s12247-008-9028-0 Gonzalez-BobesFKoppNLiLDeerbergJSharmaPLeungSDaviesMBushJHammJHrytsakMScale-up of azide chemistry: a case studyOrg. Proc. Res. Dev.2012162051205710.1021/op30026461:CAS:528:DC%2BC38XhsVKmtb3I Food and Drug Administration Code of Federal Regulations, Tittle 21, Volume 4 (21CFR210.3). ZaborenkoNLynderRBradenTCampbellBHansenMJohnsonMDevelopment of pilot-scale continuous production of an LY2886721 starting material by packed-bed hydrogenolysisOrg. Proc. Res. Dev.2015191231124310.1021/op50031771:CAS:528:DC%2BC2MXhtlOjurvL MitchellJAbhinavaKGriffithsKMcGarveyBSeibertKSethuramanSUnit operations characterization using historical manufacturing performanceInd Eng Chem Res2008476612662110.1021/ie071256h1:CAS:528:DC%2BD1cXpt1SnsL8%3D AndersonNPractical use of continuous processing in developing and scaling up laboratory processesOrg. Proc. Res. Dev.2001561362110.1021/op01006051:CAS:528:DC%2BD3MXns12lu7c%3D FigueroaIVaidyaramanSViswanathSModel-based scale-up and design space determination for a batch reactive distillation with a dean-stark trapOrg. Proc. Res. Dev.2013171300131010.1021/op40011271:CAS:528:DC%2BC3sXhtFCmu7vF TanglerASzabadosEOvercoming problems at elaboration and scale-up of liquid-phase Pd/C mediated catalytic hydrogenations in pharmaceutical productionOrg. Process Res. Dev2016201246125110.1021/acs.oprd.6b000731:CAS:528:DC%2BC28XptVKkurg%3D JohnsonMMaySCalvinJRemacleJStoutJDiseroadWZaborenkoNHaeberleBSunWMillerMBrennanJDevelopment and scale-up of a continuous, high-pressure, asymmetric hydrogenation reaction, workup, and isolationOrg. Proc. Res. Dev.2012161017103810.1021/op200362h1:CAS:528:DC%2BC38XmtFartL0%3D ICH Q11 Q9 Guidelines. CaygillGZanfirMGavriilidisAScalable reactor design for pharmaceuticals and fine chemicals production. 1: potential scale-up obstaclesOrg. Proc. Res. Dev20061053955210.1021/op050133a1:CAS:528:DC%2BD28XitVOjur4%3D L Hoekstra (9340_CR8) 2006; 10 9340_CR18 K Seibert (9340_CR2) 2008; 3 M Johnson (9340_CR11) 2012; 16 S García-Muñoz (9340_CR17) 2015; 19 F Gonzalez-Bobes (9340_CR7) 2012; 16 9340_CR14 J Mitchell (9340_CR3) 2008; 47 D Am Ende (9340_CR4) 1999; 3 A Rathore (9340_CR16) 2003; 16 C Polster (9340_CR12) 2014; 18 9340_CR1 A Tangler (9340_CR9) 2016; 20 N Thomson (9340_CR15) 2015; 19 I Figueroa (9340_CR6) 2013; 17 N Zaborenko (9340_CR13) 2015; 19 N Anderson (9340_CR10) 2001; 5 G Caygill (9340_CR5) 2006; 10 |
| References_xml | – ident: 9340_CR1 – volume: 19 start-page: 1012 year: 2015 ident: 9340_CR17 publication-title: Org. Proc. Res. Dev. doi: 10.1021/acs.oprd.5b00158 contributor: fullname: S García-Muñoz – volume: 20 start-page: 1246 year: 2016 ident: 9340_CR9 publication-title: Org. Process Res. Dev doi: 10.1021/acs.oprd.6b00073 contributor: fullname: A Tangler – volume: 10 start-page: 409 issue: 3 year: 2006 ident: 9340_CR8 publication-title: Org. Proc. Res. Dev. doi: 10.1021/op058014i contributor: fullname: L Hoekstra – volume: 16 start-page: 1017 year: 2012 ident: 9340_CR11 publication-title: Org. Proc. Res. Dev. doi: 10.1021/op200362h contributor: fullname: M Johnson – volume: 19 start-page: 1231 year: 2015 ident: 9340_CR13 publication-title: Org. Proc. Res. Dev. doi: 10.1021/op5003177 contributor: fullname: N Zaborenko – volume: 16 start-page: 34 year: 2003 ident: 9340_CR16 publication-title: BioPharm International contributor: fullname: A Rathore – volume: 47 start-page: 6612 year: 2008 ident: 9340_CR3 publication-title: Ind Eng Chem Res doi: 10.1021/ie071256h contributor: fullname: J Mitchell – volume: 3 start-page: 319 year: 1999 ident: 9340_CR4 publication-title: Org. Proc. Res. Dev doi: 10.1021/op9901801 contributor: fullname: D Am Ende – volume: 17 start-page: 1300 year: 2013 ident: 9340_CR6 publication-title: Org. Proc. Res. Dev. doi: 10.1021/op4001127 contributor: fullname: I Figueroa – ident: 9340_CR18 doi: 10.1021/acs.oprd.6b00253 – volume: 5 start-page: 613 year: 2001 ident: 9340_CR10 publication-title: Org. Proc. Res. Dev. doi: 10.1021/op0100605 contributor: fullname: N Anderson – volume: 10 start-page: 539 year: 2006 ident: 9340_CR5 publication-title: Org. Proc. Res. Dev doi: 10.1021/op050133a contributor: fullname: G Caygill – ident: 9340_CR14 – volume: 19 start-page: 935 year: 2015 ident: 9340_CR15 publication-title: Org. Proc. Res. Dev. doi: 10.1021/acs.oprd.5b00146 contributor: fullname: N Thomson – volume: 16 start-page: 2051 year: 2012 ident: 9340_CR7 publication-title: Org. Proc. Res. Dev. doi: 10.1021/op3002646 contributor: fullname: F Gonzalez-Bobes – volume: 18 start-page: 1295 year: 2014 ident: 9340_CR12 publication-title: Org Proc Res Dev doi: 10.1021/op500204z contributor: fullname: C Polster – volume: 3 start-page: 105 year: 2008 ident: 9340_CR2 publication-title: Pharm Innov doi: 10.1007/s12247-008-9028-0 contributor: fullname: K Seibert |
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| Title | Part 3: Enhanced Approaches to the Development of the Control Strategy and its Implementation in the Manufacturing Process Description |
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