Long noncoding RNA MEG8 induces an imbalance of Th17/Treg cells through the miR-107/STAT3 axis in Henoch-Schonlein purpura rats

• Published in: Aging (Albany, NY.) Vol. 15; no. 23; pp. 13854 - 13864
• Main Authors: Jiang, Mingyu, Dai, Jicheng, Jiang, Chunming, Pan, Yanbo, Ren, Mingyong, Xing, Mengnan
• Format: Journal Article
• Language: English
• Published: United States 15.12.2023
• Subjects: Animals; IgA Vasculitis - genetics; MicroRNAs - metabolism; Rats; RNA, Long Noncoding - genetics; RNA, Long Noncoding - pharmacology; T-Lymphocytes, Regulatory - metabolism; Th17 Cells; Henoch-Schonlein purpura; maternally expressed gene 8; Th17/Treg imbalance; miR-107; signal transducer and activator of transcription-3

T-helper (Th) 17/ T-regulatory (Treg) cell dysregulation underlies the pathogenesis of Henoch-Schonlein purpura (HSP). This research focused on the implication/s of the long noncoding RNA (lncRNAs) maternally expressed gene 8 (MEG8) in Th17 and Treg cell differentiation in HSP rats. MEG8, miR-107, s...