Cellular and molecular regulation of tumor necrosis factor-alpha production by pentoxofylline

• Published in: Biochemical and biophysical research communications Vol. 155; no. 3; pp. 1230 - 1236
• Main Authors: Strieter, R.M., Remick, D.G., Ward, P.A., Spengler, R.N., Lynch, J.P., Larrick, J., Kunkel, S.L.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.09.1988

Tumor necrosis factor-alpha (TNF), a mononuclear phagocyte (MO)-derived peptide, is increasingly being recognized for its pleomorphic immunologic effects. A number of investigations have demonstrated that lipopolysaccharide (LPS) can induce TNF synthesis, yet mechanisms that regulate TNF expression...