The regulatory role of the juxtamembrane region in the activity of the epidermal growth factor receptor

• Published in: Biochemical Society transactions Vol. 40; no. 1; p. 195
• Main Author: Boran, Aislyn D W
• Format: Journal Article
• Language: English
• Published: England 01.02.2012
• Subjects: Amino Acid Sequence; Calcium Signaling; Enzyme Activation; Epidermal Growth Factor - metabolism; Humans; Molecular Sequence Data; Neoplasms - enzymology; Protein Binding; Protein Interaction Domains and Motifs; Protein Transport; Receptor, Epidermal Growth Factor - chemistry; Receptor, Epidermal Growth Factor - metabolism

Although the EGFR (epidermal growth factor receptor) was discovered over 30 years ago, its mechanism of activation is still the subject of intense study. There are many published studies on the mechanism of EGFR activation and regulation, including biochemical and biophysical analyses and crystallog...