Evaluation of the efficacy of two postweaning colibacillosis vaccines in a field herd with PRRS circulation during postweaning stage
Postweaning diarrhea (PWD) and PRRS are two major concerns in swine production, which association has not been consistently explored. In the current scenario of restrictions in the use of antibiotics and ZnO, vaccination is more relevant to control PWD, but PRRS virus circulation may compromise the...
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Published in | Veterinary microbiology Vol. 285; p. 109870 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
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Elsevier B.V
01.10.2023
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Abstract | Postweaning diarrhea (PWD) and PRRS are two major concerns in swine production, which association has not been consistently explored. In the current scenario of restrictions in the use of antibiotics and ZnO, vaccination is more relevant to control PWD, but PRRS virus circulation may compromise the immune protection conferred by postweaning colibacillosis vaccines. We evaluated the efficacy of two postweaning colibacillosis vaccines (parenteral and oral) in a commercial herd affected by an outbreak of PWD and with PRRS circulation in postweaning. Five groups were studied during the postweaning period: one control (Group 1) and four vaccinated: two with each postweaning colibacillosis vaccine administered alone (Groups 2 and 3) or with sow vaccination against PRRS (Groups 4 and 5). We evaluated the effects on piglet weight, average daily weight gain and in the percentage of piglets with diarrhea, its duration, lethality and mortality. PRRS viremia and anti-PRRS antibodies were evaluated by qPCR and ELISA. Regarding control group, colibacillosis vaccination generally improved most of the measured parameters; but significant improvements were only observed in Groups 4 and 5 (p < 0.05). Moreover, cases of diarrhea occurred at different ages: in Groups 2 and 3 the peak of cases occurred just after ZnO was removed from the feed compared to Group 1, while in Groups 4 and 5 no peak was observed. This suggests that postweaning colibacillosis vaccination may be compromised by the PRRS circulation. In PRRS endemic herds an effective protection against PWD through vaccination may require PRRS vaccination to obtain a better performance.
•Colibacillosis vaccination can improve the productive parameters and mortality.•Colibacillosis vaccination efficacy is better when applied to PRRSV-protected piglets.•The efficacy of colibacillosis vaccination may be compromised by PRRSV circulation.•PRRSV sow vaccination increases the efficacy of postweaning colibacillosis vaccines. |
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AbstractList | Postweaning diarrhea (PWD) and PRRS are two major concerns in swine production, which association has not been consistently explored. In the current scenario of restrictions in the use of antibiotics and ZnO, vaccination is more relevant to control PWD, but PRRS virus circulation may compromise the immune protection conferred by postweaning colibacillosis vaccines. We evaluated the efficacy of two postweaning colibacillosis vaccines (parenteral and oral) in a commercial herd affected by an outbreak of PWD and with PRRS circulation in postweaning. Five groups were studied during the postweaning period: one control (Group 1) and four vaccinated: two with each postweaning colibacillosis vaccine administered alone (Groups 2 and 3) or with sow vaccination against PRRS (Groups 4 and 5). We evaluated the effects on piglet weight, average daily weight gain and in the percentage of piglets with diarrhea, its duration, lethality and mortality. PRRS viremia and anti-PRRS antibodies were evaluated by qPCR and ELISA. Regarding control group, colibacillosis vaccination generally improved most of the measured parameters; but significant improvements were only observed in Groups 4 and 5 (p < 0.05). Moreover, cases of diarrhea occurred at different ages: in Groups 2 and 3 the peak of cases occurred just after ZnO was removed from the feed compared to Group 1, while in Groups 4 and 5 no peak was observed. This suggests that postweaning colibacillosis vaccination may be compromised by the PRRS circulation. In PRRS endemic herds an effective protection against PWD through vaccination may require PRRS vaccination to obtain a better performance.
•Colibacillosis vaccination can improve the productive parameters and mortality.•Colibacillosis vaccination efficacy is better when applied to PRRSV-protected piglets.•The efficacy of colibacillosis vaccination may be compromised by PRRSV circulation.•PRRSV sow vaccination increases the efficacy of postweaning colibacillosis vaccines. Postweaning diarrhea (PWD) and PRRS are two major concerns in swine production, which association has not been consistently explored. In the current scenario of restrictions in the use of antibiotics and ZnO, vaccination is more relevant to control PWD, but PRRS virus circulation may compromise the immune protection conferred by postweaning colibacillosis vaccines. We evaluated the efficacy of two postweaning colibacillosis vaccines (parenteral and oral) in a commercial herd affected by an outbreak of PWD and with PRRS circulation in postweaning. Five groups were studied during the postweaning period: one control (Group 1) and four vaccinated: two with each postweaning colibacillosis vaccine administered alone (Groups 2 and 3) or with sow vaccination against PRRS (Groups 4 and 5). We evaluated the effects on piglet weight, average daily weight gain and in the percentage of piglets with diarrhea, its duration, lethality and mortality. PRRS viremia and anti-PRRS antibodies were evaluated by qPCR and ELISA. Regarding control group, colibacillosis vaccination generally improved most of the measured parameters; but significant improvements were only observed in Groups 4 and 5 (p < 0.05). Moreover, cases of diarrhea occurred at different ages: in Groups 2 and 3 the peak of cases occurred just after ZnO was removed from the feed compared to Group 1, while in Groups 4 and 5 no peak was observed. This suggests that postweaning colibacillosis vaccination may be compromised by the PRRS circulation. In PRRS endemic herds an effective protection against PWD through vaccination may require PRRS vaccination to obtain a better performance.Postweaning diarrhea (PWD) and PRRS are two major concerns in swine production, which association has not been consistently explored. In the current scenario of restrictions in the use of antibiotics and ZnO, vaccination is more relevant to control PWD, but PRRS virus circulation may compromise the immune protection conferred by postweaning colibacillosis vaccines. We evaluated the efficacy of two postweaning colibacillosis vaccines (parenteral and oral) in a commercial herd affected by an outbreak of PWD and with PRRS circulation in postweaning. Five groups were studied during the postweaning period: one control (Group 1) and four vaccinated: two with each postweaning colibacillosis vaccine administered alone (Groups 2 and 3) or with sow vaccination against PRRS (Groups 4 and 5). We evaluated the effects on piglet weight, average daily weight gain and in the percentage of piglets with diarrhea, its duration, lethality and mortality. PRRS viremia and anti-PRRS antibodies were evaluated by qPCR and ELISA. Regarding control group, colibacillosis vaccination generally improved most of the measured parameters; but significant improvements were only observed in Groups 4 and 5 (p < 0.05). Moreover, cases of diarrhea occurred at different ages: in Groups 2 and 3 the peak of cases occurred just after ZnO was removed from the feed compared to Group 1, while in Groups 4 and 5 no peak was observed. This suggests that postweaning colibacillosis vaccination may be compromised by the PRRS circulation. In PRRS endemic herds an effective protection against PWD through vaccination may require PRRS vaccination to obtain a better performance. |
ArticleNumber | 109870 |
Author | López-Novo, Cynthia Iglesias, Antonio Panadero, Rosario Díez-Baños, Pablo Díaz-Cao, José Manuel García-Dios, David Fernández, Gonzalo Prieto, Alberto López-Lorenzo, Gonzalo López, Ceferino |
Author_xml | – sequence: 1 givenname: Gonzalo surname: López-Lorenzo fullname: López-Lorenzo, Gonzalo organization: Department of Animal Pathology (INVESAGA Group), Faculty of Veterinary Sciences, Campus Terra, Universidade de Santiago de Compostela, Lugo 27002, Spain – sequence: 2 givenname: Alberto surname: Prieto fullname: Prieto, Alberto organization: Department of Animal Pathology (INVESAGA Group), Faculty of Veterinary Sciences, Campus Terra, Universidade de Santiago de Compostela, Lugo 27002, Spain – sequence: 3 givenname: José Manuel surname: Díaz-Cao fullname: Díaz-Cao, José Manuel email: josemanueldiaz.cao@usc.es organization: Department of Animal Pathology (INVESAGA Group), Faculty of Veterinary Sciences, Campus Terra, Universidade de Santiago de Compostela, Lugo 27002, Spain – sequence: 4 givenname: Cynthia surname: López-Novo fullname: López-Novo, Cynthia organization: Department of Animal Pathology (INVESAGA Group), Faculty of Veterinary Sciences, Campus Terra, Universidade de Santiago de Compostela, Lugo 27002, Spain – sequence: 5 givenname: David surname: García-Dios fullname: García-Dios, David organization: Department of Animal Pathology (INVESAGA Group), Faculty of Veterinary Sciences, Campus Terra, Universidade de Santiago de Compostela, Lugo 27002, Spain – sequence: 6 givenname: Ceferino surname: López fullname: López, Ceferino organization: Department of Animal Pathology (INVESAGA Group), Faculty of Veterinary Sciences, Campus Terra, Universidade de Santiago de Compostela, Lugo 27002, Spain – sequence: 7 givenname: Rosario surname: Panadero fullname: Panadero, Rosario organization: Department of Animal Pathology (INVESAGA Group), Faculty of Veterinary Sciences, Campus Terra, Universidade de Santiago de Compostela, Lugo 27002, Spain – sequence: 8 givenname: Antonio surname: Iglesias fullname: Iglesias, Antonio organization: Department of Anatomy, Animal Production and Veterinary Clinical Sciences, IBADER., Universidade de Santiago de Compostela, Lugo 27002, Spain – sequence: 9 givenname: Pablo surname: Díez-Baños fullname: Díez-Baños, Pablo organization: Department of Animal Pathology (INVESAGA Group), Faculty of Veterinary Sciences, Campus Terra, Universidade de Santiago de Compostela, Lugo 27002, Spain – sequence: 10 givenname: Gonzalo surname: Fernández fullname: Fernández, Gonzalo organization: Department of Animal Pathology (INVESAGA Group), Faculty of Veterinary Sciences, Campus Terra, Universidade de Santiago de Compostela, Lugo 27002, Spain |
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Keywords | Postweaning colibacillosis Swine PRRS Vaccination Diarrhea ZnO E. coli |
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Snippet | Postweaning diarrhea (PWD) and PRRS are two major concerns in swine production, which association has not been consistently explored. In the current scenario... |
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SubjectTerms | Diarrhea E. coli Postweaning colibacillosis PRRS Swine Vaccination ZnO |
Title | Evaluation of the efficacy of two postweaning colibacillosis vaccines in a field herd with PRRS circulation during postweaning stage |
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