Preparation and potential antitumor activity of alginate oligosaccharides degraded by alginate lyase from Cobetia marina

It is of great significance to develop marine resources and study its potential biological activity by using alginate lyase produced by marine psychrophilic bacteria. In the previous study, a new marine psychrophilic bacterium (Cobetia marina HQZ08) was screened from the growth area of Laminaria jap...

Full description

Saved in:
Bibliographic Details
Published inCarbohydrate research Vol. 534; p. 108962
Main Authors Qiu, Xiao-Ming, Lin, Qi, Zheng, Bing-De, Zhao, Wan-Lin, Ye, Jing, Xiao, Mei-Tian
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.12.2023
Subjects
Alginate lyase
Alginate oligosaccharides
Antitumor activity
Alginate oligosaccharides
Antitumor activity
Alginate lyase
Online AccessGet full text

Cover

Abstract It is of great significance to develop marine resources and study its potential biological activity by using alginate lyase produced by marine psychrophilic bacteria. In the previous study, a new marine psychrophilic bacterium (Cobetia marina HQZ08) was screened from the growth area of Laminaria japonica, and it was found that the strain could efficiently produce alginate-degrading enzyme (Aly30). In this paper, the ability of Aly30 to degrade alginate was optimized and the optimal degradation conditions were obtained. It was found that the main degradation product of alginate oligosaccharides was trisaccharide. In vitro cell experiments showed that the antitumor activity of low molecular weight alginate oligosaccharides was better than that of high molecular weight alginate oligosaccharides. In summary, Aly30 had the potential to produce alginate oligosaccharides with low degree of polymerization and antitumor activity, which provided a reference for the enzymatic preparation and application of alginate oligosaccharides. [Display omitted] •Alginate lyase screened from Cobetia marina HQZ08 could degrade alginate to produce oligosaccharides.•The main degradation products of alginate oligosaccharides were trisaccharides.•Low molecular weight alginate oligosaccharides had better antitumor activity.
AbstractList It is of great significance to develop marine resources and study its potential biological activity by using alginate lyase produced by marine psychrophilic bacteria. In the previous study, a new marine psychrophilic bacterium (Cobetia marina HQZ08) was screened from the growth area of Laminaria japonica, and it was found that the strain could efficiently produce alginate-degrading enzyme (Aly30). In this paper, the ability of Aly30 to degrade alginate was optimized and the optimal degradation conditions were obtained. It was found that the main degradation product of alginate oligosaccharides was trisaccharide. In vitro cell experiments showed that the antitumor activity of low molecular weight alginate oligosaccharides was better than that of high molecular weight alginate oligosaccharides. In summary, Aly30 had the potential to produce alginate oligosaccharides with low degree of polymerization and antitumor activity, which provided a reference for the enzymatic preparation and application of alginate oligosaccharides.
It is of great significance to develop marine resources and study its potential biological activity by using alginate lyase produced by marine psychrophilic bacteria. In the previous study, a new marine psychrophilic bacterium (Cobetia marina HQZ08) was screened from the growth area of Laminaria japonica, and it was found that the strain could efficiently produce alginate-degrading enzyme (Aly30). In this paper, the ability of Aly30 to degrade alginate was optimized and the optimal degradation conditions were obtained. It was found that the main degradation product of alginate oligosaccharides was trisaccharide. In vitro cell experiments showed that the antitumor activity of low molecular weight alginate oligosaccharides was better than that of high molecular weight alginate oligosaccharides. In summary, Aly30 had the potential to produce alginate oligosaccharides with low degree of polymerization and antitumor activity, which provided a reference for the enzymatic preparation and application of alginate oligosaccharides. [Display omitted] •Alginate lyase screened from Cobetia marina HQZ08 could degrade alginate to produce oligosaccharides.•The main degradation products of alginate oligosaccharides were trisaccharides.•Low molecular weight alginate oligosaccharides had better antitumor activity.
ArticleNumber 108962
Author Ye, Jing
Xiao, Mei-Tian
Zheng, Bing-De
Zhao, Wan-Lin
Lin, Qi
Qiu, Xiao-Ming
Author_xml – sequence: 1
  givenname: Xiao-Ming
  surname: Qiu
  fullname: Qiu, Xiao-Ming
  organization: Food Engineering School, Zhangzhou Institute of Technology, Zhangzhou, 363000, China
– sequence: 2
  givenname: Qi
  surname: Lin
  fullname: Lin, Qi
  organization: College of Chemical Engineering, Huaqiao University, Xiamen, 361021, China
– sequence: 3
  givenname: Bing-De
  orcidid: 0000-0001-9548-1457
  surname: Zheng
  fullname: Zheng, Bing-De
  email: bingd.zheng@hqu.edu.cn
  organization: College of Chemical Engineering, Huaqiao University, Xiamen, 361021, China
– sequence: 4
  givenname: Wan-Lin
  surname: Zhao
  fullname: Zhao, Wan-Lin
  organization: College of Chemical Engineering, Huaqiao University, Xiamen, 361021, China
– sequence: 5
  givenname: Jing
  surname: Ye
  fullname: Ye, Jing
  organization: College of Chemical Engineering, Huaqiao University, Xiamen, 361021, China
– sequence: 6
  givenname: Mei-Tian
  surname: Xiao
  fullname: Xiao, Mei-Tian
  email: mtxiao@hqu.edu.cn
  organization: College of Chemical Engineering, Huaqiao University, Xiamen, 361021, China
BookMark eNp9kE9rGzEQxUVJoY7bb9CDjrmsqz8bafcSCCZJC4H20EJvYlYauTJryZXkEH_7ymyht56GGd57zPtdk6uYIhLykbMNZ1x92m8s5IxlI5iQ7TSMSrwhKz5o2fVC_bwiK8bY0CnBb9-R61L2bWVKqxV5_ZbxCBlqSJFCdPSYKsYaYG5bDfV0SJmCreEl1DNNnsK8CxEq0jSHXSpg7S_IwWGhDncZHDo6nf-p5jMUpD6nA92mCVswPTR9hPfkrYe54Ie_c01-PD58337unr8-fdneP3dWDEPteg96dL3jo7y1WmjvmdPcgvO9ACUvXTmXYtLoJuVGy0bfO6XlJHoppRrkmtwsucecfp-wVHMIxeI8Q8R0KkYMmo2D7pVq0n6R2pxKyejNMYf27dlwZi6gzd4soM0FtFlAN9vdYsNW4yVgNsUGjBZdyGircSn8P-APze-M2Q
Cites_doi 10.3390/nu14020329
10.3390/md18030144
10.1016/j.lwt.2019.108729
10.1007/s10529-019-02722-1
10.1016/j.foodchem.2022.133045
10.3390/antiox10111842
10.1111/1541-4337.12494
10.3390/molecules28124588
10.1074/jbc.M304772200
10.1080/21655979.2015.1030543
10.1016/j.carbpol.2016.11.077
10.3390/polym12081735
10.1016/j.biortech.2020.123548
10.1016/j.carbpol.2020.117529
10.3389/fmicb.2016.01120
10.2147/DDDT.S140206
10.1016/j.watres.2019.03.068
10.1016/j.carbpol.2021.118132
10.1016/j.lfs.2005.09.039
10.3390/md17050308
10.1016/j.carbpol.2008.12.007
10.1111/j.1365-2672.2008.03988.x
10.3390/md20030159
10.1023/A:1008114709681
10.3390/microorganisms8010052
10.1016/j.carres.2011.01.023
10.1016/j.foodchem.2019.01.215
10.1016/j.ijbiomac.2022.02.126
10.1016/j.algal.2018.101389
10.1007/s10811-010-9533-7
10.1016/j.jbiosc.2018.05.012
10.1016/j.carbpol.2022.119225
10.1016/j.foodhyd.2022.107697
10.3390/foods12010220
10.1016/j.foodchem.2015.08.061
10.3390/md16090295
10.1007/s11694-022-01513-z
10.1016/j.ijbiomac.2018.08.164
10.1007/s10532-011-9489-6
10.3389/fphar.2017.00623
ContentType Journal Article
Copyright 2023 Elsevier Ltd
Copyright_xml – notice: 2023 Elsevier Ltd
DBID AAYXX
CITATION
7X8
DOI 10.1016/j.carres.2023.108962
DatabaseName CrossRef
MEDLINE - Academic
DatabaseTitle CrossRef
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic
DeliveryMethod fulltext_linktorsrc
Discipline Chemistry
EISSN 1873-426X
EndPage 108962
ExternalDocumentID 10_1016_j_carres_2023_108962
S0008621523002240
GroupedDBID ---
--K
--M
-~X
.55
.GJ
.~1
0R~
1B1
1RT
1~.
1~5
29B
4.4
457
4G.
53G
5GY
5VS
7-5
71M
8P~
9JM
9JN
AABNK
AACTN
AAEDT
AAEDW
AAIAV
AAIKJ
AAKOC
AALRI
AAOAW
AAQFI
AAQXK
AARLI
AAXUO
ABFNM
ABGSF
ABJNI
ABMAC
ABUDA
ABXDB
ABYKQ
ACDAQ
ACGFS
ACNCT
ACNNM
ACRLP
ADBBV
ADECG
ADEZE
ADMUD
ADUVX
AEBSH
AEHWI
AEKER
AENEX
AFFNX
AFKWA
AFTJW
AFXIZ
AFZHZ
AGHFR
AGRDE
AGUBO
AGYEJ
AHHHB
AHPSJ
AIEXJ
AIKHN
AITUG
AJBFU
AJOXV
AJSZI
ALMA_UNASSIGNED_HOLDINGS
AMFUW
AMRAJ
ASPBG
AVWKF
AXJTR
AZFZN
BKOJK
BLXMC
CS3
DOVZS
DU5
EBS
EFJIC
EFLBG
EJD
EO8
EO9
EP2
EP3
F5P
FDB
FEDTE
FGOYB
FIRID
FLBIZ
FNPLU
FYGXN
G-Q
GBLVA
HMS
HVGLF
HZ~
H~9
IHE
J1W
KOM
M2Z
M41
MO0
MVM
N9A
O-L
O9-
OAUVE
OZT
P-8
P-9
P2P
PC.
Q38
R2-
RIG
RNS
ROL
RPZ
SCB
SDF
SDG
SDP
SES
SEW
SOC
SPC
SPCBC
SSK
SSU
SSZ
T5K
WUQ
X7M
XPP
Y6R
YK3
ZXP
~02
~G-
~KM
AAHBH
AAXKI
AAYXX
AFJKZ
AKRWK
CITATION
7X8
ID FETCH-LOGICAL-c288t-4fa79d4d1935c727ff0d71cadf42a6310891132b7edb6d9c09f4d673b24333683
IEDL.DBID AIKHN
ISSN 0008-6215
IngestDate Fri Aug 16 21:34:17 EDT 2024
Thu Sep 26 18:39:55 EDT 2024
Fri Feb 23 02:35:18 EST 2024
IsPeerReviewed true
IsScholarly true
Keywords Alginate oligosaccharides
Antitumor activity
Alginate lyase
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c288t-4fa79d4d1935c727ff0d71cadf42a6310891132b7edb6d9c09f4d673b24333683
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ORCID 0000-0001-9548-1457
PQID 2870987466
PQPubID 23479
PageCount 1
ParticipantIDs proquest_miscellaneous_2870987466
crossref_primary_10_1016_j_carres_2023_108962
elsevier_sciencedirect_doi_10_1016_j_carres_2023_108962
PublicationCentury 2000
PublicationDate December 2023
2023-12-00
20231201
PublicationDateYYYYMMDD 2023-12-01
PublicationDate_xml – month: 12
  year: 2023
  text: December 2023
PublicationDecade 2020
PublicationTitle Carbohydrate research
PublicationYear 2023
Publisher Elsevier Ltd
Publisher_xml – name: Elsevier Ltd
References Lu, Na, Wei, Zhang, Guo (bib9) 2022; 284
Huang, Wen, Liao, Wang, Pan, Zhang, Lei, Liao, Feng, Huang (bib29) 2019; 41
Thanawiroon, Rice, Toida, Linhardt (bib30) 2004; 279
Zhu, Yin (bib36) 2015; 6
Faidi, Stumbe, Safta, Sfar (bib18) 2022; 16
Xiong, Liang, Zhang, Mahmud, Chan, Li, Lan (bib24) 2021; 10
Li, Jiang, Guan, Wang (bib38) 2011; 346
Felz, Vermeulen, van Loosdrecht, Lin (bib21) 2019; 157
An, Zhang, Wu, Zhang, Zheng, Luan, Murata, Li (bib28) 2009; 106
Sun, Zhou, Duan, Yu (bib5) 2020; 311
Chee, Wong, Wong (bib27) 2011; 23
Huang, Mendis, Rajapakse, Kim (bib40) 2006; 78
Liu, Qin, Wang (bib4) 2018; 126
Xue, Sun, Chen, Zhang, Chen, Zhang, Fan, Xu (bib15) 2022; 20
Li, Yang, Jiang, Liu, Lang, Deng, Li, Xu (bib22) 2020; 12
Vriesmann, Petkowicz (bib33) 2009; 77
Wu, Gao, Kan, Ren, Xue, Kong, Tang (bib11) 2023; 12
Wang, Chen, Bi, Ren, Han, Zhou, Han, Yao, Li (bib7) 2019; 17
Patyshakuliyeva1, Falkoski1, Wiebenga1, Timmermans, de Vries (bib13) 2020; 8
Lei, Zhang, Wang, Zheng, Miao, Lu (bib34) 2022; 388
Nova, Pimenta-Martins, Maricato, Nunes, Abreu, Coimbra, Freitas, Gomes (bib25) 2023; 28
Zhu, Zhang, Wang, Zhang, Wang, Hu, Ning, Chen (bib32) 2019; 286
Chen, Hu, Zhang, Wang, Wang, Zhang, Guo, Ji, Wang (bib10) 2017; 8
Xing, Cao, Wang, Xiao, Zhao, Zhang, Ji, Song (bib12) 2020; 18
Yang, Hu, Li, Xin, Zhao (bib31) 2021; 256
Wakabayashi, Sakatoku, Noda, Noda, Tanaka, Nakamura (bib3) 2012; 23
Zhao, Ye, Zhang, Xiao, Zhao, Huang (bib14) 2019; 59
Yang, Zhang, Qiao, Zhao, Chen, Yang, Hu, Hou, Chen (bib23) 2022; 130
Wang, Zhang, Qin, Wang, Chen, Qu, Miao (bib2) 2022; 14
Zou, Yang, Zhang, Du, Yuan, Yang, Wang (bib42) 2016; 81
Usoltseva, Shevchenko, Silchenko, Anastyuk, Zvyagintsev, Ermakova (bib20) 2022; 206
Yang, Ma, Yang, Wan, Li, Du, Lu (bib43) 2017; 11
Zhai, Li, Ren, Wang, Ma, Abd El-Aty (bib41) 2021; 266
Gao, Zhang, Li, Su, Tang, Tan, Yu, Han (bib39) 2018; 120
AOAC (bib19) 1990
Xu, Cai, Yu, Zhang, Li, Yang, Liu (bib35) 2016; 194
Liu, Yang, Li, Yan, Reaney, Jiang (bib8) 2019; 18
Fawzy, Gomaa, Hifney, Abdel-Gawad (bib16) 2017; 157
Ge, Zang, Cao, Ye, Chen (bib1) 2020; 118
Abraham, Su, Puri, Raston, Zhang (bib17) 2019; 38
Hernandez-Carmona, McHugh, Lopez-Gutierrez (bib26) 1999; 11
Zhuang, Zhang, Liu, Liu, Lyu, Ji (bib37) 2018; 16
Chen, Dong, Xu, Dong, Li, Zhang, Zhou, Zhang, Xie (bib6) 2016; 7
Ge (10.1016/j.carres.2023.108962_bib1) 2020; 118
Zhao (10.1016/j.carres.2023.108962_bib14) 2019; 59
Yang (10.1016/j.carres.2023.108962_bib31) 2021; 256
Gao (10.1016/j.carres.2023.108962_bib39) 2018; 120
Abraham (10.1016/j.carres.2023.108962_bib17) 2019; 38
AOAC (10.1016/j.carres.2023.108962_bib19) 1990
Li (10.1016/j.carres.2023.108962_bib22) 2020; 12
Wu (10.1016/j.carres.2023.108962_bib11) 2023; 12
Chen (10.1016/j.carres.2023.108962_bib10) 2017; 8
Sun (10.1016/j.carres.2023.108962_bib5) 2020; 311
Liu (10.1016/j.carres.2023.108962_bib4) 2018; 126
Faidi (10.1016/j.carres.2023.108962_bib18) 2022; 16
Huang (10.1016/j.carres.2023.108962_bib29) 2019; 41
Xing (10.1016/j.carres.2023.108962_bib12) 2020; 18
Chee (10.1016/j.carres.2023.108962_bib27) 2011; 23
Wang (10.1016/j.carres.2023.108962_bib7) 2019; 17
Liu (10.1016/j.carres.2023.108962_bib8) 2019; 18
Usoltseva (10.1016/j.carres.2023.108962_bib20) 2022; 206
Li (10.1016/j.carres.2023.108962_bib38) 2011; 346
Vriesmann (10.1016/j.carres.2023.108962_bib33) 2009; 77
An (10.1016/j.carres.2023.108962_bib28) 2009; 106
Huang (10.1016/j.carres.2023.108962_bib40) 2006; 78
Felz (10.1016/j.carres.2023.108962_bib21) 2019; 157
Xue (10.1016/j.carres.2023.108962_bib15) 2022; 20
Fawzy (10.1016/j.carres.2023.108962_bib16) 2017; 157
Zhu (10.1016/j.carres.2023.108962_bib32) 2019; 286
Zhai (10.1016/j.carres.2023.108962_bib41) 2021; 266
Xu (10.1016/j.carres.2023.108962_bib35) 2016; 194
Zhu (10.1016/j.carres.2023.108962_bib36) 2015; 6
Wang (10.1016/j.carres.2023.108962_bib2) 2022; 14
Lei (10.1016/j.carres.2023.108962_bib34) 2022; 388
Zhuang (10.1016/j.carres.2023.108962_bib37) 2018; 16
Wakabayashi (10.1016/j.carres.2023.108962_bib3) 2012; 23
Chen (10.1016/j.carres.2023.108962_bib6) 2016; 7
Hernandez-Carmona (10.1016/j.carres.2023.108962_bib26) 1999; 11
Xiong (10.1016/j.carres.2023.108962_bib24) 2021; 10
Nova (10.1016/j.carres.2023.108962_bib25) 2023; 28
Lu (10.1016/j.carres.2023.108962_bib9) 2022; 284
Patyshakuliyeva1 (10.1016/j.carres.2023.108962_bib13) 2020; 8
Zou (10.1016/j.carres.2023.108962_bib42) 2016; 81
Thanawiroon (10.1016/j.carres.2023.108962_bib30) 2004; 279
Yang (10.1016/j.carres.2023.108962_bib23) 2022; 130
Yang (10.1016/j.carres.2023.108962_bib43) 2017; 11
References_xml – volume: 14
  start-page: 329
  year: 2022
  ident: bib2
  article-title: Physicochemical properties of the soluble dietary fiber from
  publication-title: Nutrients
  contributor:
    fullname: Miao
– volume: 12
  start-page: 220
  year: 2023
  ident: bib11
  article-title: Alginate oligosaccharides prevent dextran-sulfate-sodium-induced ulcerative colitis via enhancing intestinal barrier function and modulating gut microbiota
  publication-title: Foods
  contributor:
    fullname: Tang
– volume: 286
  start-page: 129
  year: 2019
  end-page: 135
  ident: bib32
  article-title: Pectin oligosaccharides from hawthorn (
  publication-title: Food Chem.
  contributor:
    fullname: Chen
– volume: 23
  start-page: 93
  year: 2012
  end-page: 105
  ident: bib3
  article-title: Isolation and characterization of
  publication-title: Biodegradation
  contributor:
    fullname: Nakamura
– volume: 38
  year: 2019
  ident: bib17
  article-title: Optimisation of biorefinery production of alginate, fucoidan and laminarin from brown seaweed
  publication-title: Algal Res.
  contributor:
    fullname: Zhang
– volume: 256
  year: 2021
  ident: bib31
  article-title: Structural characterization and effect on leukopenia of fucoidan from
  publication-title: Carbohydr. Polym.
  contributor:
    fullname: Zhao
– volume: 8
  start-page: 623
  year: 2017
  ident: bib10
  article-title: Alginate oligosaccharide DP5 exhibits antitumor effects in osteosarcoma patients following surgery
  publication-title: Front. Pharmacol.
  contributor:
    fullname: Wang
– volume: 18
  start-page: 1859
  year: 2019
  end-page: 1881
  ident: bib8
  article-title: Alginate oligosaccharides: production, biological activities, and potential applications
  publication-title: Compr. Rev. Food Sci. Food Saf.
  contributor:
    fullname: Jiang
– volume: 28
  start-page: 4588
  year: 2023
  ident: bib25
  article-title: Chemical composition and antioxidant potential of five algae cultivated in fully controlled closed systems
  publication-title: Molecules
  contributor:
    fullname: Gomes
– volume: 8
  start-page: 52
  year: 2020
  ident: bib13
  article-title: Macroalgae derived fungi have high abilities to degrade algal polymers
  publication-title: Microorganisms
  contributor:
    fullname: de Vries
– volume: 279
  start-page: 2608
  year: 2004
  end-page: 2615
  ident: bib30
  article-title: Glycobiology and extracellular matrices-liquid chromatography/mass spectrometry sequencing approach for highly sulfated heparin-derived oligosaccharides
  publication-title: J. Biol. Chem.
  contributor:
    fullname: Linhardt
– volume: 17
  start-page: 308
  year: 2019
  ident: bib7
  article-title: Characterization of an alkaline alginate ayase with pH-stable and thermo-tolerance property
  publication-title: Mar. Drugs
  contributor:
    fullname: Li
– volume: 130
  year: 2022
  ident: bib23
  article-title: Cascaded membrane and chromatography technologies for fractionating and purifying of bovine milk oligosaccharides
  publication-title: Food Hydrocolloids.
  contributor:
    fullname: Chen
– volume: 77
  start-page: 72
  year: 2009
  end-page: 79
  ident: bib33
  article-title: Polysaccharides from the pulp of cupuassu (
  publication-title: Carbohydr. Polym.
  contributor:
    fullname: Petkowicz
– volume: 11
  start-page: 493
  year: 1999
  end-page: 502
  ident: bib26
  article-title: Pilot plant scale extraction of alginates from
  publication-title: J. Appl. Phycol.
  contributor:
    fullname: Lopez-Gutierrez
– volume: 11
  start-page: 2565
  year: 2017
  end-page: 2579
  ident: bib43
  article-title: Alginate oligosaccharide indirectly affects toll-like receptor signaling via the inhibition of microRNA-29b in aneurysm patients after endovascular aortic repair
  publication-title: Drug Des. Dev. Ther.
  contributor:
    fullname: Lu
– volume: 7
  start-page: 1120
  year: 2016
  ident: bib6
  article-title: Characterization of a new cold-adapted and salt-activated polysaccharide lyase Family 7 alginate lyase from
  publication-title: Front. Microbiol.
  contributor:
    fullname: Xie
– volume: 18
  start-page: 144
  year: 2020
  ident: bib12
  article-title: Advances in research on the bioactivity of alginate oligosaccharides
  publication-title: Mar. Drugs
  contributor:
    fullname: Song
– volume: 10
  start-page: 1842
  year: 2021
  ident: bib24
  article-title: Characterization, antioxidant and antitumor activities of oligosaccharides isolated from
  publication-title: Antioxidants
  contributor:
    fullname: Lan
– volume: 20
  start-page: 190
  year: 2022
  ident: bib15
  article-title: A novel alginate lyase: identification, characterization, and potential application in alginate trisaccharide preparation
  publication-title: Mar. Drugs
  contributor:
    fullname: Xu
– volume: 157
  start-page: 201
  year: 2019
  end-page: 208
  ident: bib21
  article-title: Chemical characterization methods for the analysis of structural extracellular polymeric substances (EPS)
  publication-title: Water Res.
  contributor:
    fullname: Lin
– volume: 41
  start-page: 1187
  year: 2019
  end-page: 1200
  ident: bib29
  article-title: Characterization of a bifunctional alginate lyase as a new member of the polysaccharide lyase family 17 from a
  publication-title: Biotechnol. Lett.
  contributor:
    fullname: Huang
– year: 1990
  ident: bib19
  article-title: Official Methods of Analysis of the Association of Official Analytical Chemistry
  contributor:
    fullname: AOAC
– volume: 194
  start-page: 650
  year: 2016
  end-page: 658
  ident: bib35
  article-title: Optimisation of pressurised water extraction of polysaccharides from blackcurrant and its antioxidant activity
  publication-title: Food Chem.
  contributor:
    fullname: Liu
– volume: 78
  start-page: 2399
  year: 2006
  end-page: 2408
  ident: bib40
  article-title: Strong electronic charge as an important factor for anticancer activity of chitooligosaccharides (COS)
  publication-title: Life Sci.
  contributor:
    fullname: Kim
– volume: 59
  start-page: 169
  year: 2019
  end-page: 180
  ident: bib14
  article-title: Screening, identification and fermentation optimization of an alginate-degrading strain
  publication-title: Acta Microbiol. Sin.
  contributor:
    fullname: Huang
– volume: 118
  year: 2020
  ident: bib1
  article-title: Rheological properties, textural and compound preservative of kelp recombination noodles
  publication-title: LWT-Food Sci. Technol.
  contributor:
    fullname: Chen
– volume: 266
  year: 2021
  ident: bib41
  article-title: The impact of chitooligosaccharides and their derivatives on the in vitro and in vivo antitumor activity: a comprehensive review
  publication-title: Carbohydr. Polym.
  contributor:
    fullname: Abd El-Aty
– volume: 81
  start-page: H3035
  year: 2016
  end-page: H3042
  ident: bib42
  article-title: Antitumor effects of orally and intraperitoneally administered chitosan oligosaccharides (COSs) on S180-Bearing/Residual Mouse
  publication-title: Food Sci. (N. Y.)
  contributor:
    fullname: Wang
– volume: 6
  start-page: 125
  year: 2015
  end-page: 131
  ident: bib36
  article-title: Alginate lyase: review of major sources and classification, properties, structure-function analysis and applications
  publication-title: Bioengineered
  contributor:
    fullname: Yin
– volume: 157
  start-page: 1903
  year: 2017
  end-page: 1912
  ident: bib16
  article-title: Optimization of alginate alkaline extraction technology from
  publication-title: Carbohydr. Polym.
  contributor:
    fullname: Abdel-Gawad
– volume: 23
  start-page: 191
  year: 2011
  end-page: 196
  ident: bib27
  article-title: Extraction and characterisation of alginate from brown seaweeds (
  publication-title: J. Appl. Phycol.
  contributor:
    fullname: Wong
– volume: 106
  start-page: 161
  year: 2009
  end-page: 170
  ident: bib28
  article-title: Alginate-deriving oligosaccharide production by alginase from newly isolated
  publication-title: J. Appl. Microbiol.
  contributor:
    fullname: Li
– volume: 16
  start-page: 295
  year: 2018
  ident: bib37
  article-title: Characterization of a novel polyM-preferred alginate lyase from
  publication-title: Mar. Drugs
  contributor:
    fullname: Ji
– volume: 311
  year: 2020
  ident: bib5
  article-title: Hydrolyzing
  publication-title: Bio Technol.
  contributor:
    fullname: Yu
– volume: 206
  start-page: 614
  year: 2022
  end-page: 620
  ident: bib20
  article-title: Determination of the structure and in vitro anticancer activity of fucan from
  publication-title: Int. J. Biol. Macromol.
  contributor:
    fullname: Ermakova
– volume: 126
  start-page: 710
  year: 2018
  end-page: 714
  ident: bib4
  article-title: Characteristics of hydrogen-producing enrichment cultures from marine sediment using macroalgae
  publication-title: J. Biosci. Bioeng.
  contributor:
    fullname: Wang
– volume: 16
  start-page: 4457
  year: 2022
  end-page: 4469
  ident: bib18
  article-title: Implementation of response surface methodology for the optimization of the extraction of sodium alginate from
  publication-title: Food Measure
  contributor:
    fullname: Sfar
– volume: 12
  start-page: 1735
  year: 2020
  ident: bib22
  article-title: Glycerin/NaOH aqueous solution as a green solvent system for dissolution of cellulose
  publication-title: Polymers
  contributor:
    fullname: Xu
– volume: 284
  year: 2022
  ident: bib9
  article-title: Alginate oligosaccharides: the structure-function relationships and the directional preparation for application
  publication-title: Carbohydr. Polym.
  contributor:
    fullname: Guo
– volume: 388
  year: 2022
  ident: bib34
  article-title: Structural characterization and in vitro analysis of the prebiotic activity of oligosaccharides from lotus (
  publication-title: Food Chem.
  contributor:
    fullname: Lu
– volume: 120
  start-page: 729
  year: 2018
  end-page: 735
  ident: bib39
  article-title: Characterization of a new endo-type polysaccharide lyase (PL) family 6 alginate lyase with cold-adapted and metal ions-resisted property
  publication-title: Int. J. Biol. Macromol.
  contributor:
    fullname: Han
– volume: 346
  start-page: 794
  year: 2011
  end-page: 800
  ident: bib38
  article-title: Preparation, purification and characterization of alginate oligosaccharides degraded by alginate lyase from
  publication-title: Carbohydr. Res.
  contributor:
    fullname: Wang
– volume: 14
  start-page: 329
  issue: 2
  year: 2022
  ident: 10.1016/j.carres.2023.108962_bib2
  article-title: Physicochemical properties of the soluble dietary fiber from laminaria japonica and its role in the regulation of Type 2 diabetes mice
  publication-title: Nutrients
  doi: 10.3390/nu14020329
  contributor:
    fullname: Wang
– volume: 18
  start-page: 144
  issue: 3
  year: 2020
  ident: 10.1016/j.carres.2023.108962_bib12
  article-title: Advances in research on the bioactivity of alginate oligosaccharides
  publication-title: Mar. Drugs
  doi: 10.3390/md18030144
  contributor:
    fullname: Xing
– volume: 118
  year: 2020
  ident: 10.1016/j.carres.2023.108962_bib1
  article-title: Rheological properties, textural and compound preservative of kelp recombination noodles
  publication-title: LWT-Food Sci. Technol.
  doi: 10.1016/j.lwt.2019.108729
  contributor:
    fullname: Ge
– volume: 41
  start-page: 1187
  issue: 10
  year: 2019
  ident: 10.1016/j.carres.2023.108962_bib29
  article-title: Characterization of a bifunctional alginate lyase as a new member of the polysaccharide lyase family 17 from a marine strain BP-2
  publication-title: Biotechnol. Lett.
  doi: 10.1007/s10529-019-02722-1
  contributor:
    fullname: Huang
– volume: 388
  year: 2022
  ident: 10.1016/j.carres.2023.108962_bib34
  article-title: Structural characterization and in vitro analysis of the prebiotic activity of oligosaccharides from lotus (Nelumbo nucifera Gaertn.) seeds
  publication-title: Food Chem.
  doi: 10.1016/j.foodchem.2022.133045
  contributor:
    fullname: Lei
– volume: 10
  start-page: 1842
  issue: 11
  year: 2021
  ident: 10.1016/j.carres.2023.108962_bib24
  article-title: Characterization, antioxidant and antitumor activities of oligosaccharides isolated from Evodia lepta (Spreng) Merr. by different extraction methods
  publication-title: Antioxidants
  doi: 10.3390/antiox10111842
  contributor:
    fullname: Xiong
– volume: 18
  start-page: 1859
  issue: 6
  year: 2019
  ident: 10.1016/j.carres.2023.108962_bib8
  article-title: Alginate oligosaccharides: production, biological activities, and potential applications
  publication-title: Compr. Rev. Food Sci. Food Saf.
  doi: 10.1111/1541-4337.12494
  contributor:
    fullname: Liu
– volume: 28
  start-page: 4588
  issue: 12
  year: 2023
  ident: 10.1016/j.carres.2023.108962_bib25
  article-title: Chemical composition and antioxidant potential of five algae cultivated in fully controlled closed systems
  publication-title: Molecules
  doi: 10.3390/molecules28124588
  contributor:
    fullname: Nova
– volume: 279
  start-page: 2608
  issue: 4
  year: 2004
  ident: 10.1016/j.carres.2023.108962_bib30
  article-title: Glycobiology and extracellular matrices-liquid chromatography/mass spectrometry sequencing approach for highly sulfated heparin-derived oligosaccharides
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M304772200
  contributor:
    fullname: Thanawiroon
– volume: 6
  start-page: 125
  issue: 3
  year: 2015
  ident: 10.1016/j.carres.2023.108962_bib36
  article-title: Alginate lyase: review of major sources and classification, properties, structure-function analysis and applications
  publication-title: Bioengineered
  doi: 10.1080/21655979.2015.1030543
  contributor:
    fullname: Zhu
– volume: 157
  start-page: 1903
  year: 2017
  ident: 10.1016/j.carres.2023.108962_bib16
  article-title: Optimization of alginate alkaline extraction technology from Sargassum latifolium and its potential antioxidant and emulsifying properties
  publication-title: Carbohydr. Polym.
  doi: 10.1016/j.carbpol.2016.11.077
  contributor:
    fullname: Fawzy
– volume: 12
  start-page: 1735
  issue: 8
  year: 2020
  ident: 10.1016/j.carres.2023.108962_bib22
  article-title: Glycerin/NaOH aqueous solution as a green solvent system for dissolution of cellulose
  publication-title: Polymers
  doi: 10.3390/polym12081735
  contributor:
    fullname: Li
– volume: 311
  year: 2020
  ident: 10.1016/j.carres.2023.108962_bib5
  article-title: Hydrolyzing Laminaria japonica with a combination of microbial alginate lyase and cellulase
  publication-title: Bio Technol.
  doi: 10.1016/j.biortech.2020.123548
  contributor:
    fullname: Sun
– volume: 256
  year: 2021
  ident: 10.1016/j.carres.2023.108962_bib31
  article-title: Structural characterization and effect on leukopenia of fucoidan from Durvillaea antarctica
  publication-title: Carbohydr. Polym.
  doi: 10.1016/j.carbpol.2020.117529
  contributor:
    fullname: Yang
– volume: 7
  start-page: 1120
  year: 2016
  ident: 10.1016/j.carres.2023.108962_bib6
  article-title: Characterization of a new cold-adapted and salt-activated polysaccharide lyase Family 7 alginate lyase from Pseudoalteromonas sp. SM0524
  publication-title: Front. Microbiol.
  doi: 10.3389/fmicb.2016.01120
  contributor:
    fullname: Chen
– volume: 11
  start-page: 2565
  year: 2017
  ident: 10.1016/j.carres.2023.108962_bib43
  article-title: Alginate oligosaccharide indirectly affects toll-like receptor signaling via the inhibition of microRNA-29b in aneurysm patients after endovascular aortic repair
  publication-title: Drug Des. Dev. Ther.
  doi: 10.2147/DDDT.S140206
  contributor:
    fullname: Yang
– volume: 157
  start-page: 201
  year: 2019
  ident: 10.1016/j.carres.2023.108962_bib21
  article-title: Chemical characterization methods for the analysis of structural extracellular polymeric substances (EPS)
  publication-title: Water Res.
  doi: 10.1016/j.watres.2019.03.068
  contributor:
    fullname: Felz
– volume: 266
  year: 2021
  ident: 10.1016/j.carres.2023.108962_bib41
  article-title: The impact of chitooligosaccharides and their derivatives on the in vitro and in vivo antitumor activity: a comprehensive review
  publication-title: Carbohydr. Polym.
  doi: 10.1016/j.carbpol.2021.118132
  contributor:
    fullname: Zhai
– volume: 78
  start-page: 2399
  issue: 20
  year: 2006
  ident: 10.1016/j.carres.2023.108962_bib40
  article-title: Strong electronic charge as an important factor for anticancer activity of chitooligosaccharides (COS)
  publication-title: Life Sci.
  doi: 10.1016/j.lfs.2005.09.039
  contributor:
    fullname: Huang
– volume: 17
  start-page: 308
  issue: 5
  year: 2019
  ident: 10.1016/j.carres.2023.108962_bib7
  article-title: Characterization of an alkaline alginate ayase with pH-stable and thermo-tolerance property
  publication-title: Mar. Drugs
  doi: 10.3390/md17050308
  contributor:
    fullname: Wang
– volume: 77
  start-page: 72
  issue: 1
  year: 2009
  ident: 10.1016/j.carres.2023.108962_bib33
  article-title: Polysaccharides from the pulp of cupuassu (Theobroma grandiflorum): structural characterization of a pectic fraction
  publication-title: Carbohydr. Polym.
  doi: 10.1016/j.carbpol.2008.12.007
  contributor:
    fullname: Vriesmann
– volume: 106
  start-page: 161
  issue: 1
  year: 2009
  ident: 10.1016/j.carres.2023.108962_bib28
  article-title: Alginate-deriving oligosaccharide production by alginase from newly isolated Flavobacterium sp. LXA and its potential application in protection against pathogens
  publication-title: J. Appl. Microbiol.
  doi: 10.1111/j.1365-2672.2008.03988.x
  contributor:
    fullname: An
– volume: 20
  start-page: 190
  issue: 3
  year: 2022
  ident: 10.1016/j.carres.2023.108962_bib15
  article-title: A novel alginate lyase: identification, characterization, and potential application in alginate trisaccharide preparation
  publication-title: Mar. Drugs
  doi: 10.3390/md20030159
  contributor:
    fullname: Xue
– volume: 11
  start-page: 493
  issue: 6
  year: 1999
  ident: 10.1016/j.carres.2023.108962_bib26
  article-title: Pilot plant scale extraction of alginates from Macrocystis pyrifera. 2. Studies on extraction conditions andmethods of separating the alkaline-insoluble residue
  publication-title: J. Appl. Phycol.
  doi: 10.1023/A:1008114709681
  contributor:
    fullname: Hernandez-Carmona
– volume: 8
  start-page: 52
  issue: 1
  year: 2020
  ident: 10.1016/j.carres.2023.108962_bib13
  article-title: Macroalgae derived fungi have high abilities to degrade algal polymers
  publication-title: Microorganisms
  doi: 10.3390/microorganisms8010052
  contributor:
    fullname: Patyshakuliyeva1
– volume: 346
  start-page: 794
  issue: 6
  year: 2011
  ident: 10.1016/j.carres.2023.108962_bib38
  article-title: Preparation, purification and characterization of alginate oligosaccharides degraded by alginate lyase from Pseudomonas sp HZJ 216
  publication-title: Carbohydr. Res.
  doi: 10.1016/j.carres.2011.01.023
  contributor:
    fullname: Li
– volume: 286
  start-page: 129
  year: 2019
  ident: 10.1016/j.carres.2023.108962_bib32
  article-title: Pectin oligosaccharides from hawthorn (Crataegus pinnatifida Bunge. Var. major): molecular characterization and potential antiglycation activities
  publication-title: Food Chem.
  doi: 10.1016/j.foodchem.2019.01.215
  contributor:
    fullname: Zhu
– volume: 206
  start-page: 614
  year: 2022
  ident: 10.1016/j.carres.2023.108962_bib20
  article-title: Determination of the structure and in vitro anticancer activity of fucan from Saccharina dentigera and its derivatives
  publication-title: Int. J. Biol. Macromol.
  doi: 10.1016/j.ijbiomac.2022.02.126
  contributor:
    fullname: Usoltseva
– volume: 38
  year: 2019
  ident: 10.1016/j.carres.2023.108962_bib17
  article-title: Optimisation of biorefinery production of alginate, fucoidan and laminarin from brown seaweed Durvillaea potatorum
  publication-title: Algal Res.
  doi: 10.1016/j.algal.2018.101389
  contributor:
    fullname: Abraham
– volume: 23
  start-page: 191
  issue: 2
  year: 2011
  ident: 10.1016/j.carres.2023.108962_bib27
  article-title: Extraction and characterisation of alginate from brown seaweeds (Fucales, Phaeophyceae) collected from Port Dickson, Peninsular Malaysia
  publication-title: J. Appl. Phycol.
  doi: 10.1007/s10811-010-9533-7
  contributor:
    fullname: Chee
– year: 1990
  ident: 10.1016/j.carres.2023.108962_bib19
  contributor:
    fullname: AOAC
– volume: 126
  start-page: 710
  issue: 6
  year: 2018
  ident: 10.1016/j.carres.2023.108962_bib4
  article-title: Characteristics of hydrogen-producing enrichment cultures from marine sediment using macroalgae Laminaria japonica as a feedstock
  publication-title: J. Biosci. Bioeng.
  doi: 10.1016/j.jbiosc.2018.05.012
  contributor:
    fullname: Liu
– volume: 284
  year: 2022
  ident: 10.1016/j.carres.2023.108962_bib9
  article-title: Alginate oligosaccharides: the structure-function relationships and the directional preparation for application
  publication-title: Carbohydr. Polym.
  doi: 10.1016/j.carbpol.2022.119225
  contributor:
    fullname: Lu
– volume: 130
  year: 2022
  ident: 10.1016/j.carres.2023.108962_bib23
  article-title: Cascaded membrane and chromatography technologies for fractionating and purifying of bovine milk oligosaccharides
  publication-title: Food Hydrocolloids.
  doi: 10.1016/j.foodhyd.2022.107697
  contributor:
    fullname: Yang
– volume: 81
  start-page: H3035
  issue: 12
  year: 2016
  ident: 10.1016/j.carres.2023.108962_bib42
  article-title: Antitumor effects of orally and intraperitoneally administered chitosan oligosaccharides (COSs) on S180-Bearing/Residual Mouse
  publication-title: Food Sci. (N. Y.)
  contributor:
    fullname: Zou
– volume: 12
  start-page: 220
  issue: 1
  year: 2023
  ident: 10.1016/j.carres.2023.108962_bib11
  article-title: Alginate oligosaccharides prevent dextran-sulfate-sodium-induced ulcerative colitis via enhancing intestinal barrier function and modulating gut microbiota
  publication-title: Foods
  doi: 10.3390/foods12010220
  contributor:
    fullname: Wu
– volume: 194
  start-page: 650
  year: 2016
  ident: 10.1016/j.carres.2023.108962_bib35
  article-title: Optimisation of pressurised water extraction of polysaccharides from blackcurrant and its antioxidant activity
  publication-title: Food Chem.
  doi: 10.1016/j.foodchem.2015.08.061
  contributor:
    fullname: Xu
– volume: 59
  start-page: 169
  issue: 1
  year: 2019
  ident: 10.1016/j.carres.2023.108962_bib14
  article-title: Screening, identification and fermentation optimization of an alginate-degrading strain
  publication-title: Acta Microbiol. Sin.
  contributor:
    fullname: Zhao
– volume: 16
  start-page: 295
  issue: 9
  year: 2018
  ident: 10.1016/j.carres.2023.108962_bib37
  article-title: Characterization of a novel polyM-preferred alginate lyase from Marine Vibrio splendidus OU02
  publication-title: Mar. Drugs
  doi: 10.3390/md16090295
  contributor:
    fullname: Zhuang
– volume: 16
  start-page: 4457
  issue: 6
  year: 2022
  ident: 10.1016/j.carres.2023.108962_bib18
  article-title: Implementation of response surface methodology for the optimization of the extraction of sodium alginate from Padina pavonica brown algae
  publication-title: Food Measure
  doi: 10.1007/s11694-022-01513-z
  contributor:
    fullname: Faidi
– volume: 120
  start-page: 729
  year: 2018
  ident: 10.1016/j.carres.2023.108962_bib39
  article-title: Characterization of a new endo-type polysaccharide lyase (PL) family 6 alginate lyase with cold-adapted and metal ions-resisted property
  publication-title: Int. J. Biol. Macromol.
  doi: 10.1016/j.ijbiomac.2018.08.164
  contributor:
    fullname: Gao
– volume: 23
  start-page: 93
  issue: 1
  year: 2012
  ident: 10.1016/j.carres.2023.108962_bib3
  article-title: Isolation and characterization of Microbulbifer species 6532A degrading seaweed thalli to single cell detritus particles
  publication-title: Biodegradation
  doi: 10.1007/s10532-011-9489-6
  contributor:
    fullname: Wakabayashi
– volume: 8
  start-page: 623
  year: 2017
  ident: 10.1016/j.carres.2023.108962_bib10
  article-title: Alginate oligosaccharide DP5 exhibits antitumor effects in osteosarcoma patients following surgery
  publication-title: Front. Pharmacol.
  doi: 10.3389/fphar.2017.00623
  contributor:
    fullname: Chen
SSID ssj0000676
Score 2.4571047
Snippet It is of great significance to develop marine resources and study its potential biological activity by using alginate lyase produced by marine psychrophilic...
SourceID proquest
crossref
elsevier
SourceType Aggregation Database
Publisher
StartPage 108962
SubjectTerms Alginate lyase
Alginate oligosaccharides
Antitumor activity
Title Preparation and potential antitumor activity of alginate oligosaccharides degraded by alginate lyase from Cobetia marina
URI https://dx.doi.org/10.1016/j.carres.2023.108962
https://search.proquest.com/docview/2870987466
Volume 534
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1dS9xAFL3o7kN9EWtb_KgyBV-nZjOTmeRRFmXbpYtIRd_CfJaV3cyyZkFf_O2du0lQCyL0KSTMhHBmOPcmOedegBOvbKJ1IqkcKEa5SzxVWcFofGOWMUHwigs0J_-aiNE1_3mb3W7AsPPCoKyy5f6G09ds3V45bdE8XUyn6PHFdHyAnzXXgWkT-jEccd6D_tmP8WjykpBFkwXnFCd0Drq1zMugIhbrdqcM9XaFSN-KUP9w9ToAXezAdps5krPm4T7Chqt24cOwa9j2CR4ul66p5B0qoipLFqFGLVCcpNCMu5qHJUEfA7aLIMETNcOmDLUjYTb9E-6VQQvW1Lp7YrGEhHWW6MfnUbPHGPEI-lHIMGgXb0zmcXylPsP1xfnv4Yi2jRWoSfO8ptwrWVhuY_KWmZjAeJ9YOTDKep4qwRAGbECvpbNa2MIkhedWSKZTzhgTOfsCvSpUbg-IiuspU2XTNLecZ0XuIoVoluU6M8ZwvQ-0A7NcNPUzyk5Ydlc24JcIftmAvw-yQ7x8tQ_KSPHvzPzWLVAZgcf_HqpyYRUHRU4qcsmFOPjvux_CFp41Qpav0KuXK3cU05FaH8Pm96fBcbvp8Di-uhn_BdUt4rE
link.rule.ids 315,786,790,4521,24144,27955,27956,45618,45712
linkProvider Elsevier
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3LTuMwFLUKs4DNCOah6fDySGw9pLFjJ0tUgQpTEAsqdWf5Oeqojas2lWDDt-Obh2YYCSGxTWwrurbOPUnOuRehU69sonUiiBgoSphLPFFZQUl8YxaRIHjFOJiTb275aMKup9m0h4adFwZklS32N5heo3V75ayN5tlyNgOPL9DxAXzWrBPTFvoAbAB0XT-fBv_CMW84cE5geOefq0VeBvSwULU7paC2K3j6Wn76D6nr9HO5hz62vBGfN4-2j3qu_IR2hl27ts_o4W7lmjreocSqtHgZKlACxUkKrLibRVhhcDFAswgcPFZzaMlQORzms99hrQwYsGbWrbGFAhLWWawf_46aP8Z8h8GNgodBu7gwXsTxpfqCJpcX98MRadsqEJPmeUWYV6KwzEbqlplIX7xPrBgYZT1LFacQBmg_r4WzmtvCJIVnlguqU0Yp5Tn9irbLULpvCKu4myJVNk1zy1hW5C4CiKZZrjNjDNN9RLpgymVTPUN2srI_sgm-hODLJvh9JLqIyxenQEaAf2Pmj26DZAw8_PVQpQubOCgiUpELxvn3d69-gnZG9zdjOb66_XWAduFOI2k5RNvVauOOIjGp9HF98J4ByLfh4w
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Preparation+and+potential+antitumor+activity+of+alginate+oligosaccharides+degraded+by+alginate+lyase+from+Cobetia+marina&rft.jtitle=Carbohydrate+research&rft.au=Qiu%2C+Xiao-Ming&rft.au=Lin%2C+Qi&rft.au=Zheng%2C+Bing-De&rft.au=Zhao%2C+Wan-Lin&rft.date=2023-12-01&rft.pub=Elsevier+Ltd&rft.issn=0008-6215&rft.eissn=1873-426X&rft.volume=534&rft_id=info:doi/10.1016%2Fj.carres.2023.108962&rft.externalDocID=S0008621523002240
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0008-6215&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0008-6215&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0008-6215&client=summon