Transcription factor 7-like 2 (TCF7L2): a culprit gene in Type 2 Diabetes Mellitus

• Published in: Sakharnyĭ diabet Vol. 24; no. 4; pp. 371 - 376
• Main Authors: Jan, A., Jan, H., Ullah, Z.
• Format: Journal Article
• Language: English
• Published: Endocrinology Research Centre 01.01.2021
• Subjects: genome wise association studies (gwas); transcription factor-7– like 2 (tcf7l2); type 2 diabetes; wnt signaling pathways

The genetics of Type 2 diabetes a complex metabolic disorder, characterized by decreased insulin secretion and insulin resistance resulting in impaired blood glucose homeostasis remains enigma for geneticists. In 2006 an important step while finding genetic causes of diabetes type 2 was identificati...