Synthesis, crystal structure, biological evaluation, electronic aspects of hydrogen bonds, and QSAR studies of some new N-(substituted phenylurea) diazaphosphore derivatives as anticancer agents

• Published in: Medicinal chemistry research Vol. 25; no. 4; pp. 769 - 789
• Main Authors: Dorosti, Niloufar, Delfan, Bahram, Gholivand, Khodayar, Valmoozi, Ali Asghar Ebrahimi
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.04.2016
• Subjects: Biochemistry; Biomedical and Life Sciences; Biomedicine; Cell Biology; Original Research; Pharmacology/Toxicology; NBO; Antibacterial; Anticancer; Diazaphosphore; QSAR; AIM

A new series of 2-[ N -( R -phenylureido)]-1,3,2-diazaphosphore-2-oxide derivatives ( R  = CH 3 , F, NO 2 , CN) were synthesized and characterized by 31 P, 1 H, 13 C NMR and FT-IR spectral techniques. All the compounds were evaluated for their antibacterial activity against some Gram-positive, Gram-...