Anti-microbial benzimidazole derivatives: synthesis and in vitro biological evaluation

In this study, we have synthesized 5-(nitro/chloro)-2-styryl-benzimidazoles and evaluated for in vitro anti-microbial activity with different strain like anti-bacterial activity against Staphylococcus aureus , Escherichia coli , and anti-fungal activity against Candida albicans were carried out. Com...

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Bibliographic Details
Published inMedicinal chemistry research Vol. 21; no. 12; pp. 4330 - 4334
Main Authors Soni, Love Kumar, Narsinghani, Tamanna, Sethi, Anand
Format Journal Article
LanguageEnglish
Published New York Springer-Verlag 01.12.2012
Subjects
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Original Research
Pharmacology/Toxicology
Anti-microbial activity
2-Styryl benzimidazole
Anti-fungal activity
Anti-bacterial activity
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Summary:In this study, we have synthesized 5-(nitro/chloro)-2-styryl-benzimidazoles and evaluated for in vitro anti-microbial activity with different strain like anti-bacterial activity against Staphylococcus aureus , Escherichia coli , and anti-fungal activity against Candida albicans were carried out. Compounds 2 , 4 , 7 , 8 showed higher activity against S. aureus , compounds 2 , 8 , 9 , 10 showed higher activity against E. coli and Compounds 2 , 7 , 9 , 8 showed higher activity against C. albicans .
ISSN:1054-2523
1554-8120
DOI:10.1007/s00044-012-9976-2