Microvascular and Macrovascular Complications of Diabetes
Animal studies have suggested that treatment with antioxidants, such as vitamin E, may attenuate some vascular dysfunction associated with diabetes, but treatment with antioxidants has not yet been shown to alter the development or progression of retinopathy or other microvascular complications of d...
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| Published in | Clinical diabetes Vol. 26; no. 2; pp. 77 - 82 |
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| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
Alexandria
American Diabetes Association
01.04.2008
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0891-8929 1945-4953 |
| DOI | 10.2337/diaclin.26.2.77 |
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| Abstract | Animal studies have suggested that treatment with antioxidants, such as vitamin E, may attenuate some vascular dysfunction associated with diabetes, but treatment with antioxidants has not yet been shown to alter the development or progression of retinopathy or other microvascular complications of diabetes.1,6 Growth factors, including vascular endothelial growth factor (VEGF), growth hormone, and transforming growth factor β, have also been postulated to play important roles in the development of diabetic retinopathy. Combination therapy with a statin plus other drugs, such as fibrates or niacin, may be necessary to achieve ideal lipid control, but patients should be monitored closely for possible adverse reactions of therapy.15 Aspirin therapy (75-162 mg/day) is indicated in secondary prevention of CVD and should be used in patients with diabetes who are > 40 years of age and in those who are 30-40 years of age if other risk factors are present. |
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| AbstractList | Animal studies have suggested that treatment with antioxidants, such as vitamin E, may attenuate some vascular dysfunction associated with diabetes, but treatment with antioxidants has not yet been shown to alter the development or progression of retinopathy or other microvascular complications of diabetes.1,6 Growth factors, including vascular endothelial growth factor (VEGF), growth hormone, and transforming growth factor β, have also been postulated to play important roles in the development of diabetic retinopathy. Combination therapy with a statin plus other drugs, such as fibrates or niacin, may be necessary to achieve ideal lipid control, but patients should be monitored closely for possible adverse reactions of therapy.15 Aspirin therapy (75-162 mg/day) is indicated in secondary prevention of CVD and should be used in patients with diabetes who are > 40 years of age and in those who are 30-40 years of age if other risk factors are present. |
| Audience | Professional Academic |
| Author | Fowler, Michael J. |
| Author_xml | – sequence: 1 givenname: Michael J. surname: Fowler fullname: Fowler, Michael J. |
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| ContentType | Journal Article |
| Copyright | COPYRIGHT 2008 American Diabetes Association Copyright American Diabetes Association Spring 2008 |
| Copyright_xml | – notice: COPYRIGHT 2008 American Diabetes Association – notice: Copyright American Diabetes Association Spring 2008 |
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| Discipline | Medicine |
| EISSN | 1945-4953 |
| EndPage | 82 |
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| SubjectTerms | ACE inhibitors Blood pressure Cardiovascular disease Care and treatment Complications and side effects Diabetes Diabetic nephropathies Diabetic retinopathy Diagnosis Drug therapy Free radicals Glucose Growth hormones Hyperglycemia Intervention Mortality Risk factors |
| Title | Microvascular and Macrovascular Complications of Diabetes |
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