Novel fluorescent triazinobenzimidazole derivatives as probes for labelling human A1 and A2B adenosine receptor subtypes

• Published in: Bioorganic & medicinal chemistry Vol. 26; no. 22; pp. 5885 - 5895
• Main Authors: Barresi, Elisabetta, Giacomelli, Chiara, Daniele, Simona, Tonazzini, Ilaria, Robello, Marco, Salerno, Silvia, Piano, Ilaria, Cosimelli, Barbara, Greco, Giovanni, Da Settimo, Federico, Martini, Claudia, Trincavelli, Maria Letizia, Taliani, Sabrina
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.12.2018
• Subjects: A2B AR subtype; Adenosine receptors; Fluorescent probes; Mesenchymal stem cells; Triazinobenzimidazole derivatives; Triazinobenzimidazole derivatives; A2B AR subtype; Adenosine receptors; Fluorescent probes; Mesenchymal stem cells

[Display omitted] The expression levels and the subcellular localization of adenosine receptors (ARs) are affected in several pathological conditions as a consequence of changes in adenosine release and metabolism. In this respect, labelled probes able to monitor the AR expression could be a useful...