Combination of Diosmetin With Chrysin Against Hepatocellular Carcinoma Through Inhibiting PI3K/AKT/mTOR/NF‐кB Signaling Pathway: TCGA Analysis, Molecular Docking, Molecular Dynamics, In Vitro Experiment

• Published in: Chemical biology & drug design Vol. 104; no. 4; pp. e70003 - n/a
• Main Authors: Yu, Xiang, Zhang, Di, Hu, Chengming, Yu, Zejun, Li, Yang, Fang, Cheng, Qiu, Yinsheng, Mei, Zhinan, Xu, Lingyun
• Format: Journal Article
• Language: English
• Published: England 01.10.2024
• Subjects: Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; apoptosis; Apoptosis - drug effects; autophagy; Autophagy - drug effects; Carcinoma, Hepatocellular - drug therapy; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - pathology; Cell Line, Tumor; chrysin; diosmetin; Flavonoids - chemistry; Flavonoids - pharmacology; Hep G2 Cells; hepatocellular carcinoma; Humans; Liver Neoplasms - drug therapy; Liver Neoplasms - metabolism; Liver Neoplasms - pathology; Molecular Docking Simulation; molecular dynamics; Molecular Dynamics Simulation; NF-kappa B - metabolism; Phosphatidylinositol 3-Kinases - metabolism; PI3K/AKT/mTOR/NF‐кB signaling pathway; Proto-Oncogene Proteins c-akt - metabolism; Signal Transduction - drug effects; TOR Serine-Threonine Kinases - antagonists & inhibitors; TOR Serine-Threonine Kinases - metabolism; autophagy; PI3K/AKT/mTOR/NF‐кB signaling pathway; apoptosis; chrysin; molecular dynamics; hepatocellular carcinoma; diosmetin
• ISSN: 1747-0277; 1747-0285; 1747-0285
• DOI: 10.1111/cbdd.70003

ABSTRACT Hepatocellular carcinoma (HCC) is the sixth most prevalent malignant tumor. Hepatocellular carcinogenesis is closely linked to apoptosis, autophagy, and inflammation. Diosmetin and chrysin, are two flavonoid compounds, exhibit anti‐inflammatory and anticancer properties. In this study, the...