Combination of Diosmetin With Chrysin Against Hepatocellular Carcinoma Through Inhibiting PI3K/AKT/mTOR/NF‐кB Signaling Pathway: TCGA Analysis, Molecular Docking, Molecular Dynamics, In Vitro Experiment - Yu, Xiang; Zhang, Di; Hu, Chengming; Yu, Zejun; Li, Yang; Fang, Cheng; Qiu, Yinsheng; Mei, Zhinan; Xu, Lingyun (Chemical biology & drug design, 2024)
Keywords: Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; apoptosis; Apoptosis - drug effects; autophagy; Autophagy - drug effects; Carcinoma, Hepatocellular - drug therapy; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - pathology; Cell Line, Tumor; chrysin; diosmetin; Flavonoids - chemistry; Flavonoids - pharmacology; Hep G2 Cells; hepatocellular carcinoma; Humans; Liver Neoplasms - drug therapy; Liver Neoplasms - metabolism; Liver Neoplasms - pathology; Molecular Docking Simulation; molecular dynamics; Molecular Dynamics Simulation; NF-kappa B - metabolism; Phosphatidylinositol 3-Kinases - metabolism; PI3K/AKT/mTOR/NF‐кB signaling pathway; Proto-Oncogene Proteins c-akt - metabolism; Signal Transduction - drug effects; TOR Serine-Threonine Kinases - antagonists & inhibitors; TOR Serine-Threonine Kinases - metabolism; autophagy; PI3K/AKT/mTOR/NF‐кB signaling pathway; apoptosis; chrysin; molecular dynamics; hepatocellular carcinoma; diosmetin