Mesenchymal stem cells and cell-derived extracellular vesicles protect hippocampal neurons from oxidative stress and synapse damage induced by amyloid-β oligomers

• Published in: The Journal of biological chemistry Vol. 293; no. 6; pp. 1957 - 1975
• Main Authors: de Godoy, Mariana A., Saraiva, Leonardo M., de Carvalho, Luiza R.P., Vasconcelos-dos-Santos, Andreia, Beiral, Hellen J.V., Ramos, Alane Bernardo, Silva, Livian R. de Paula, Leal, Renata B., Monteiro, Victor H.S., Braga, Carolina V., de Araujo-Silva, Carlla A., Sinis, Leandro C., Bodart-Santos, Victor, Kasai-Brunswick, Tais Hanae, Alcantara, Carolina de Lima, Lima, Ana Paula C.A., da Cunha-e Silva, Narcisa L., Galina, Antonio, Vieyra, Adalberto, De Felice, Fernanda G., Mendez-Otero, Rosalia, Ferreira, Sergio T.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 09.02.2018; American Society for Biochemistry and Molecular Biology
• Subjects: Alzheimer Disease - genetics; Alzheimer Disease - metabolism; Alzheimer’s disease; Amyloid beta-Peptides - chemistry; Amyloid beta-Peptides - metabolism; amyloid-β; Animals; catalase; Cell Biology; Cells, Cultured; Coculture Techniques; cytokine action; endocytosis; extracellular vesicles; Extracellular Vesicles - genetics; Extracellular Vesicles - metabolism; hippocampus; Hippocampus - cytology; Hippocampus - metabolism; Humans; Interleukin-10 - metabolism; Interleukin-6 - metabolism; Male; mesenchymal stem cells (MSCs); Mesenchymal Stem Cells - cytology; Mesenchymal Stem Cells - metabolism; Neurons - cytology; Neurons - metabolism; oligomers; Oxidative Stress; Rats; Rats, Wistar; synapse; Synapses - metabolism; Vascular Endothelial Growth Factor A - metabolism; extracellular vesicles; Alzheimer’s disease; hippocampus; mesenchymal stem cells (MSCs); oligomers; amyloid-β; endocytosis; synapse; catalase; oxidative stress; cytokine action; Alzheimer's disease

Alzheimer’s disease (AD) is a disabling and highly prevalent neurodegenerative condition, for which there are no effective therapies. Soluble oligomers of the amyloid-β peptide (AβOs) are thought to be proximal neurotoxins involved in early neuronal oxidative stress and synapse damage, ultimately le...