Effect of lathyrane-type diterpenoids in neural stem cell physiology: Microbial transformations, molecular docking and dynamics studies

• Published in: Bioorganic chemistry Vol. 153; p. 107769
• Main Authors: Escobar-Montaño, Felipe, Gómez-Oliva, Ricardo, Ezzanad, Abdellah, Vázquez de Górgolas, Sonia, Zorrilla, David, Macías-Sánchez, Antonio J., Botubol-Ares, José M., Nunez-Abades, Pedro, Castro, Carmen, Durán-Patrón, Rosa, Hernández-Galán, Rosario
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2024
• Subjects: Biotransformation; Lathyrane; Molecular docking; Molecular dynamics; Mucor circinelloides; NRG1; NSC; TGFα; Biotransformation; Mucor circinelloides; Molecular dynamics; TGFα; Lathyrane; NRG1; Molecular docking; NSC

[Display omitted] •Mucor circinelloides transformed lathyranes 4 and 5 into nine derivatives, including jatrophane derivatives.•Compounds 12 induces NRG1 release and differentiation of NSC into neurons like other novel PKC activating compounds.•Compound 12 binds to the PKC enzyme pocket via hydrogen...