Synthesis of novel polysubstituted N-benzyl-1H-pyrroles via a cascade reaction of alkynyl Fischer carbenes with alpha-imino glycine methyl esters
An efficient and simple synthesis of novel and densely substituted N-benzyl-1H-pyrroles 6a-r is described by a 1,4-addition/isomerization/ring closure/demetalation cascade process of alkynyl Fischer carbene complexes 1a-f and 2a and a-imino glycine methyl esters 3a, b, d, g, h, and k promoted with L...
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Published in | Organic & biomolecular chemistry Vol. 13; no. 48; pp. 11753 - 11760 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
CAMBRIDGE
Royal Soc Chemistry
28.12.2015
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Subjects | |
Online Access | Get full text |
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Summary: | An efficient and simple synthesis of novel and densely substituted N-benzyl-1H-pyrroles 6a-r is described by a 1,4-addition/isomerization/ring closure/demetalation cascade process of alkynyl Fischer carbene complexes 1a-f and 2a and a-imino glycine methyl esters 3a, b, d, g, h, and k promoted with LDA. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1477-0520 1477-0539 |
DOI: | 10.1039/c5ob01655j |