The regulatory roles of NADPH oxidase, intra- and extra-cellular HSP70 in pancreatic islet function, dysfunction and diabetes

• Published in: Clinical science (1979) Vol. 128; no. 11; pp. 789 - 803
• Main Authors: Krause, Mauricio, Bock, Patricia Martins, Takahashi, Hilton Kenji, Homem De Bittencourt, Paulo Ivo, Newsholme, Philip
• Format: Journal Article
• Language: English
• Published: England 01.06.2015
• Subjects: Diabetes Mellitus, Type 2 - metabolism; Diabetes Mellitus, Type 2 - physiopathology; Extracellular Space - metabolism; Glucagon-Secreting Cells - metabolism; Glucagon-Secreting Cells - physiology; HSP70 Heat-Shock Proteins - metabolism; Humans; Insulin-Secreting Cells - metabolism; Insulin-Secreting Cells - physiology; Intracellular Space - metabolism; Islets of Langerhans - metabolism; Islets of Langerhans - physiology; NADPH Oxidases - metabolism; Signal Transduction - physiology

The 70 kDa heat-shock protein (HSP70) family is important for a dynamic range of cellular processes that include protection against cell stress, modulation of cell signalling, gene expression, protein synthesis, protein folding and inflammation. Within this family, the inducible 72 kDa and the cogna...