Corticoid receptors in rat brain: evidence for an aldosterone receptor

• Published in: Endocrinology (Philadelphia) Vol. 98; no. 3; p. 676
• Main Authors: Anderson, 3rd, N S, Fanestil, D D
• Format: Journal Article
• Language: English
• Published: United States 01.03.1976
• Subjects: Aldosterone - pharmacology; Animals; Binding Sites; Brain - drug effects; Corticosterone - pharmacology; Cytosol - drug effects; Dexamethasone - pharmacology; Macromolecular Substances; Male; Rats; Receptors, Cell Surface; Spironolactone - pharmacology

The existence of high and low affinity mineralocorticoid-binding macromolecules (receptors) has been demonstrated in vitro in cytosols derived from the adrenalectomized rat brain by the specific binding of [3H]aldosterone (3H-A). The high-affinity aldosterone sites can be distinguished from those si...