Drosophila lipin interacts with insulin and TOR signaling pathways in the control of growth and lipid metabolism

• Published in: Journal of cell science Vol. 128; no. 23; p. 4395
• Main Authors: Schmitt, Sandra, Ugrankar, Rupali, Greene, Stephanie E., Prajapati, Meenakshi, Lehmann, Michael
• Format: Journal Article
• Language: English
• Published: England 01.12.2015
• Subjects: Active Transport, Cell Nucleus - physiology; Animals; Cell Nucleus - genetics; Cell Nucleus - metabolism; Drosophila melanogaster; Drosophila Proteins - genetics; Drosophila Proteins - metabolism; Lipid Metabolism - physiology; Mechanistic Target of Rapamycin Complex 1; Multiprotein Complexes - genetics; Multiprotein Complexes - metabolism; Phosphatidylinositol 3-Kinases - genetics; Phosphatidylinositol 3-Kinases - metabolism; Proto-Oncogene Proteins c-akt - genetics; Proto-Oncogene Proteins c-akt - metabolism; Signal Transduction - physiology; TOR Serine-Threonine Kinases - genetics; TOR Serine-Threonine Kinases - metabolism; Lipin; TOR signaling; Insulin signaling

Lipin proteins have key functions in lipid metabolism, acting as both phosphatidate phosphatases (PAPs) and nuclear regulators of gene expression. We show that the insulin and TORC1 pathways independently control functions of Drosophila dLipin. Reduced signaling through the insulin receptor strongly...