Reprogramming of cells during embryonic transfating: overcoming a reprogramming block

• Published in: Development (Cambridge) Vol. 151; no. 24
• Main Authors: Berrio, Alejandro, Miranda, Esther, Massri, Abdull J., Afanassiev, Anton, Schiebinger, Geoffrey, Wray, Gregory A., McClay, David R.
• Format: Journal Article
• Language: English
• Published: England 15.12.2024
• Subjects: Animals; Cell Differentiation; Cell Lineage; Cellular Reprogramming - genetics; Embryo, Nonmammalian - cytology; Embryo, Nonmammalian - metabolism; Embryonic Development - genetics; Endoderm - cytology; Endoderm - metabolism; Gene Expression Regulation, Developmental; Mesoderm - cytology; Mesoderm - embryology; Mesoderm - metabolism; Sea Urchins - cytology; Sea Urchins - embryology; Signal Transduction; Gene regulatory network; Regeneration; scRNA-seq; Reprogramming; Sea urchin; Delta-Notch

Regulative development, demonstrated by many animal embryos, is the ability to replace missing cells or parts. The underlying molecular mechanism(s) of that ability is not well understood. If sea urchin micromeres (skeletogenic cell progenitors) are removed at the 16-cell stage, early endoderm initi...