Helical folding in heterogeneous foldamers without inter-residual backbone hydrogen-bonding

• Published in: Chemical communications (Cambridge, England) Vol. 48; no. 71; pp. 8922 - 8924
• Main Authors: Priya, Gowri, Kotmale, Amol S, Gawade, Rupesh L, Mishra, Deepti, Pal, Sourav, Puranik, Vedavadi G, Rajamohanan, Pattuparambil R, Sanjayan, Gangadhar J
• Format: Journal Article
• Language: English
• Published: England 14.09.2012
• Subjects: Amino Acids - chemistry; Carboxylic Acids - chemistry; Crystallography, X-Ray; Hydrogen - chemistry; Hydrogen Bonding; Peptides - chemistry; Peptides - metabolism; Protein Folding; Protein Structure, Secondary; Thiophenes - chemistry

This communication describes a set of hybrid foldamers that do not feature inter-residual, but intra-residual backbone hydrogen-bonding, yet adopt a preferentially folded conformation displaying right-handed helical architecture. Conformational ordering is apparently due to the combined conformation...