On the catalytic mechanism of dimeric dUTPases

• Published in: Biochemical journal Vol. 456; no. 1; p. 81
• Main Authors: Hemsworth, Glyn R, González-Pacanowska, Dolores, Wilson, Keith S
• Format: Journal Article
• Language: English
• Published: England 15.11.2013
• Subjects: Catalysis; Crystallography, X-Ray; Humans; Protein Conformation; Protein Multimerization; Pyrophosphatases - antagonists & inhibitors; Pyrophosphatases - chemistry; Solutions; Substrate Specificity; Trypanosoma brucei brucei - enzymology

The Tritryps Trypanosoma brucei, Trypanosoma cruzi and Leishmania donovani are responsible for great morbidity and mortality in developing countries. Their dimeric dUTPases are members of the all-α NTP pyrophosphohydrolase family and represent promising drug targets due to their essential nature and...