Bacterial pathogen gene regulation: a DNA-structure-centred view of a protein-dominated domain

• Published in: Clinical science (1979) Vol. 130; no. 14; pp. 1165 - 1177
• Main Authors: Dorman, Charles J., Colgan, Aoife, Dorman, Matthew J.
• Format: Journal Article
• Language: English
• Published: England 01.07.2016
• Subjects: DNA, Bacterial - chemistry; DNA, Superhelical - chemistry; DNA-Binding Proteins - chemistry; Gene Expression Regulation, Bacterial; Protein Domains; Virulence - genetics; DNA supercoiling; transcription factor; RNA; nucleoid-associated protein; transcription; DNA; bacterial pathogen

The mechanisms used by bacterial pathogens to regulate the expression of their genes, especially their virulence genes, have been the subject of intense investigation for several decades. Whole genome sequencing projects, together with more targeted studies, have identified hundreds of DNA-binding p...