Synthesis and anticancer activity of silver( i )–N-heterocyclic carbene complexes derived from the natural xanthine products caffeine, theophylline and theobromine

• Published in: Dalton transactions : an international journal of inorganic chemistry Vol. 44; no. 16; pp. 7563 - 7569
• Main Authors: Mohamed, Heba A., Lake, Benjamin R. M., Laing, Thomas, Phillips, Roger M., Willans, Charlotte E.
• Format: Journal Article
• Language: English
• Published: England 28.04.2015
• Subjects: Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Antineoplastic Agents - toxicity; Biological Products - chemistry; Caffeine - chemistry; Cell Line, Tumor; Cell Survival - drug effects; Coordination Complexes - chemical synthesis; Coordination Complexes - chemistry; Coordination Complexes - toxicity; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Heterocyclic Compounds - chemistry; Humans; Hydrophobic and Hydrophilic Interactions; Methane - analogs & derivatives; Methane - chemistry; Molecular Conformation; Silver - chemistry; Theobromine - chemistry; Theophylline - chemistry; Xanthine - chemistry

A new library of silver( i )–N-heterocyclic carbene complexes prepared from the natural products caffeine, theophylline and theobromine is reported. The complexes have been fully characterised using a combination of NMR spectroscopy, mass spectrometry, elemental analysis and X-ray diffraction analys...