Expression of hnRNP A2/B1 proteins in human cancer cell lines

The overexpression of heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1 is recently reported informative as a marker of lung cancer for early detection. To examine whether the expression of the proteins is specific for lung cancer, immunological analyses were performed both in lung and non-lung...

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Published inInternational journal of oncology Vol. 16; no. 4; p. 763
Main Authors Satoh, H, Kamma, H, Ishikawa, H, Horiguchi, H, Fujiwara, M, Yamashita, Y T, Ohtsuka, M, Sekizawa, K
Format Journal Article
LanguageEnglish
Published Greece 01.04.2000
Subjects
Heterogeneous-Nuclear Ribonucleoprotein Group A-B
Heterogeneous-Nuclear Ribonucleoproteins
Humans
Immunoblotting
Lung Neoplasms - chemistry
Microscopy, Fluorescence
Neoplasms - chemistry
Ribonucleoproteins - analysis
Tumor Cells, Cultured
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Summary:The overexpression of heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1 is recently reported informative as a marker of lung cancer for early detection. To examine whether the expression of the proteins is specific for lung cancer, immunological analyses were performed both in lung and non-lung cancer cell lines. In immunostaining and Western blotting, the expression of A2/B1 was observed not only in the lung cancer cells but also in non-lung cancer cells. The expression of hnRNP A2/B1 is not specific for lung cancer and quantitative determination of A2/B1 is required to elucidate their significance in carcinogenesis.
ISSN:1019-6439
DOI:10.3892/ijo.16.4.763