Spatial proteomic alterations detected via MALDI-MS imaging implicate neuronal loss in a Huntington's disease mouse (YAC128) brain

• Published in: Molecular omics Vol. 18; no. 4; pp. 336 - 347
• Main Authors: Karayel-Basar, Merve, Uras, Irep, Kiris, Irem, Sahin, Betul, Akgun, Emel, Baykal, Ahmet Tarik
• Format: Journal Article
• Language: English
• Published: England 11.05.2022
• Subjects: Animals; Brain - metabolism; Chromatography, Liquid; Huntington Disease - diagnostic imaging; Huntington Disease - genetics; Huntington Disease - metabolism; Mice; Proteomics; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods; Tandem Mass Spectrometry

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder that occurs with the increase of CAG trinucleotide repeats in the gene. To understand the mechanisms of HD, powerful proteomics techniques, such as liquid chromatography-tandem mass spectrometry (LC-MS/MS) were employ...