A common polymorphism in the annexin V Kozak sequence (−1C>T) increases translation efficiency and plasma levels of annexin V, and decreases the risk of myocardial infarction in young patients

• Published in: Blood Vol. 100; no. 6; pp. 2081 - 2086
• Main Authors: González-Conejero, Rocio, Corral, Javier, Roldán, Vanessa, Martı́nez, Constantino, Marı́n, Francisco, Rivera, José, Iniesta, Juan A., Lozano, Marı́a L., Marco, Pascual, Vicente, Vicente
• Format: Journal Article
• Language: English
• Published: 15.09.2002

Annexin V has phospholipid-binding capacity and plays a potent antithrombotic role. Recently, a C to T transition has been described in the Kozak region of this gene, affecting the nucleotide preceding the initiation ATG codon. We have developed a simple method to detect this genetic change, showing...