Paraoxonase-1 overexpression prevents experimental abdominal aortic aneurysm progression

• Published in: Clinical science (1979) Vol. 130; no. 12; pp. 1027 - 1038
• Main Authors: Burillo, Elena, Tarin, Carlos, Torres-Fonseca, Monica-Maria, Fernandez-García, Carlos-Ernesto, Martinez-Pinna, Roxana, Martinez-Lopez, Diego, Llamas-Granda, Patricia, Camafeita, Emilio, Lopez, Juan Antonio, Vega de Ceniga, Melina, Aviram, Michael, Egido, Jesus, Blanco-Colio, Luis-Miguel, Martín-Ventura, Jose-Luis
• Format: Journal Article
• Language: English
• Published: England 01.06.2016
• Subjects: Animals; Aortic Aneurysm, Abdominal - metabolism; Aortic Aneurysm, Abdominal - prevention & control; Apoptosis - drug effects; Aryldialkylphosphatase - metabolism; Disease Models, Animal; Disease Progression; Humans; Inflammation - metabolism; Macrophages - metabolism; Male; Mice; Mice, Transgenic; Proteomics - methods; paraoxonase-1; proteomics; immune-inflammatory response; abdominal aortic aneurysm; oxidative stress

Abdominal aortic aneurysm (AAA) is a permanent dilation of the aorta due to excessive proteolytic, oxidative and inflammatory injury of the aortic wall. We aimed to identify novel mediators involved in AAA pathophysiology, which could lead to novel therapeutic approaches. For that purpose, plasma fr...