A convenient and efficient 4-(diethylamino)-butylamine-labeled polarity-response-homodispersed strategy for absolute quantification of carboxyl submetabolome: Monitoring the whole progressive course of hepatocellular carcinoma
•A convenient and efficient workflow for absolute quantification of carboxyl submetabolome was established based on the DEABA-labeled polarity-response-homodispersed strategy.•Carboxyl submetabolome profiling in the whole course of hepatocellular carcinoma was monitored.•Combined with analysis of va...
Saved in:
| Published in | Journal of Chromatography A Vol. 1683; p. 463504 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Elsevier B.V
08.11.2022
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0021-9673 |
| DOI | 10.1016/j.chroma.2022.463504 |
Cover
Loading…
| Abstract | •A convenient and efficient workflow for absolute quantification of carboxyl submetabolome was established based on the DEABA-labeled polarity-response-homodispersed strategy.•Carboxyl submetabolome profiling in the whole course of hepatocellular carcinoma was monitored.•Combined with analysis of variance (ANOVA), orthogonal partial least squares discrimination analysis (OPLS-DA) and Bayesian linear discriminant analysis (BLDA), the biomarkers were screened out and the diagnostic model was established.
Recent studies have shown that dysregulation of carboxyl submetabolome homeostasis is closely related to the occurrence and development of hepatocellular carcinoma (HCC). However, it is still a challenge to quantify carboxyl metabolites with high efficiency by conventional methods due to their species diversity and nature differences. Moreover, there are few studies on carboxyl submetabolome profiling during the whole progression of HCC. In this study, a convenient and efficient workflow for absolute quantification of carboxyl submetabolome was established based on the 4-(diethylamino)-butylamine (DEABA)-labeled polarity-response-homodispersed strategy. After optimizing derivation conditions with response surface methodology (RSM), the reaction only needed 1 min at room temperature, which radically simplified the labeling process. Compared with nonderivatization, the gaps of polarities and responses of the analytes were narrowed by DEABA labeling, realizing the polarity-response-homodispersion. Then resolution and sensitivity in HPLC-MS/MS were improved significantly. Ultimately, the workflow was applied to monitor carboxyl metabolic profile in human plasma of the whole progressive course of hepatocellular carcinoma. Combined with analysis of variance (ANOVA), orthogonal partial least squares discrimination analysis (OPLS-DA), Bayesian linear discriminant analysis (BLDA) and other data mining methods, the biomarkers of “health-hepatitis-cirrhosis-HCC” were screened out, and the diagnostic model was established. Furthermore, the relevancy between carboxyl submetabolome disorders and the pathogenesis of HCC was investigated. The developed method has the characteristics of high sensitivity, high coverage and high practicability, which is suitable for the study of biomarkers of carboxyl submetabolome in the whole progression of HCC.
[Display omitted] |
|---|---|
| AbstractList | Recent studies have shown that dysregulation of carboxyl submetabolome homeostasis is closely related to the occurrence and development of hepatocellular carcinoma (HCC). However, it is still a challenge to quantify carboxyl metabolites with high efficiency by conventional methods due to their species diversity and nature differences. Moreover, there are few studies on carboxyl submetabolome profiling during the whole progression of HCC. In this study, a convenient and efficient workflow for absolute quantification of carboxyl submetabolome was established based on the 4-(diethylamino)-butylamine (DEABA)-labeled polarity-response-homodispersed strategy. After optimizing derivation conditions with response surface methodology (RSM), the reaction only needed 1 min at room temperature, which radically simplified the labeling process. Compared with nonderivatization, the gaps of polarities and responses of the analytes were narrowed by DEABA labeling, realizing the polarity-response-homodispersion. Then resolution and sensitivity in HPLC-MS/MS were improved significantly. Ultimately, the workflow was applied to monitor carboxyl metabolic profile in human plasma of the whole progressive course of hepatocellular carcinoma. Combined with analysis of variance (ANOVA), orthogonal partial least squares discrimination analysis (OPLS-DA), Bayesian linear discriminant analysis (BLDA) and other data mining methods, the biomarkers of “health-hepatitis-cirrhosis-HCC” were screened out, and the diagnostic model was established. Furthermore, the relevancy between carboxyl submetabolome disorders and the pathogenesis of HCC was investigated. The developed method has the characteristics of high sensitivity, high coverage and high practicability, which is suitable for the study of biomarkers of carboxyl submetabolome in the whole progression of HCC. •A convenient and efficient workflow for absolute quantification of carboxyl submetabolome was established based on the DEABA-labeled polarity-response-homodispersed strategy.•Carboxyl submetabolome profiling in the whole course of hepatocellular carcinoma was monitored.•Combined with analysis of variance (ANOVA), orthogonal partial least squares discrimination analysis (OPLS-DA) and Bayesian linear discriminant analysis (BLDA), the biomarkers were screened out and the diagnostic model was established. Recent studies have shown that dysregulation of carboxyl submetabolome homeostasis is closely related to the occurrence and development of hepatocellular carcinoma (HCC). However, it is still a challenge to quantify carboxyl metabolites with high efficiency by conventional methods due to their species diversity and nature differences. Moreover, there are few studies on carboxyl submetabolome profiling during the whole progression of HCC. In this study, a convenient and efficient workflow for absolute quantification of carboxyl submetabolome was established based on the 4-(diethylamino)-butylamine (DEABA)-labeled polarity-response-homodispersed strategy. After optimizing derivation conditions with response surface methodology (RSM), the reaction only needed 1 min at room temperature, which radically simplified the labeling process. Compared with nonderivatization, the gaps of polarities and responses of the analytes were narrowed by DEABA labeling, realizing the polarity-response-homodispersion. Then resolution and sensitivity in HPLC-MS/MS were improved significantly. Ultimately, the workflow was applied to monitor carboxyl metabolic profile in human plasma of the whole progressive course of hepatocellular carcinoma. Combined with analysis of variance (ANOVA), orthogonal partial least squares discrimination analysis (OPLS-DA), Bayesian linear discriminant analysis (BLDA) and other data mining methods, the biomarkers of “health-hepatitis-cirrhosis-HCC” were screened out, and the diagnostic model was established. Furthermore, the relevancy between carboxyl submetabolome disorders and the pathogenesis of HCC was investigated. The developed method has the characteristics of high sensitivity, high coverage and high practicability, which is suitable for the study of biomarkers of carboxyl submetabolome in the whole progression of HCC. [Display omitted] |
| ArticleNumber | 463504 |
| Author | Zhang, Qian Xing, Luwen Bi, Kaishun Li, Qing Tong, Minghui Zhang, Yiwen |
| Author_xml | – sequence: 1 givenname: Minghui surname: Tong fullname: Tong, Minghui – sequence: 2 givenname: Qian surname: Zhang fullname: Zhang, Qian – sequence: 3 givenname: Yiwen surname: Zhang fullname: Zhang, Yiwen – sequence: 4 givenname: Luwen surname: Xing fullname: Xing, Luwen – sequence: 5 givenname: Kaishun surname: Bi fullname: Bi, Kaishun – sequence: 6 givenname: Qing orcidid: 0000-0003-3087-4692 surname: Li fullname: Li, Qing email: lqyxm@hotmail.com |
| BookMark | eNqFUctu1DAUzaJIfdA_YOFlWWTq2Jmk0wVSVQFFKmLTri0_biYeOb6p7QzN7_IlOA0rFrCyLZ-XzjkvTjx6KIoPFd1UtGquDxvdBxzkhlHGNnXDt7Q-Kc4oZVW5a1p-WpzHeKC0amnLzopfd0SjP4K34BOR3hDoOqvfXnV5ZSykfnZysB4_lmpK6x1KJxU4MGREJ4NNcxkgjugjlD0OaGwcIcT8H1OQCfYz6TAQqSK6KQF5maRPNvvIZNET7IiWQeHr7Eic1ABJKnQ4wC35jt4mDNbvSeqB_OzRARkD7rNftEfI6adstEj0MMqEGpybcqZFUefUg3xfvOuki3D557wonr98frp_KB9_fP12f_dYanbTppLtOFNcaskVpbRRXG8N3SpleM1uVNdUknOtZa21NqB4q5VudwY6w7ZNV7eMXxRXq26O9zJBTGKwcYkjPeAUBcuYKoNpk6H1CtUBYwzQiTHYQYZZVFQsM4qDWGcUy4xinTHTbv-iaZveKswtW_c_8qeVDLmDo4Ug4jKzBmMD6CQM2n8L_AZLqsku |
| CitedBy_id | crossref_primary_10_3390_ijms24054258 |
| Cites_doi | 10.1016/j.talanta.2017.01.038 10.1038/s41419-020-2257-y 10.1038/s41598-019-55600-1 10.1038/s41575-018-0089-3 10.1021/acs.analchem.7b05355 10.1016/j.jpba.2019.112815 10.1053/j.gastro.2010.12.006 10.1002/ijc.33588 10.1002/hep.29914 10.1016/j.aca.2020.04.064 10.5551/jat.RV17006 10.3389/fimmu.2018.01853 10.1016/j.pharmthera.2020.107670 10.1021/acs.analchem.8b03435 10.1002/hep.29033 10.1016/j.cclet.2017.06.009 10.1016/j.trac.2020.115988 10.1016/j.jare.2018.03.005 10.1016/j.cca.2012.12.024 10.1371/journal.pone.0092864 10.1002/advs.202100311 10.1038/nrgastro.2017.119 10.1038/nrgastro.2013.151 10.1080/10717544.2021.1914776 10.1111/jpi.12060 10.3390/cancers13112648 10.1007/s10555-018-9747-8 10.1038/s41575-020-00404-2 10.1016/j.jpba.2021.114066 10.1016/j.jchromb.2019.121771 10.1038/s41586-019-0904-1 10.1093/carcin/bgs367 10.1016/j.chroma.2020.460869 10.1161/CIRCULATIONAHA.118.036652 10.1053/j.gastro.2013.01.001 10.2147/JHC.S338353 10.2147/CMAR.S183376 10.18632/aging.103751 10.1016/j.ejphar.2012.10.032 10.3390/nu7115475 10.1016/j.jhep.2017.03.011 10.1016/j.ab.2018.12.006 10.1016/j.cclet.2022.01.004 10.1038/nature16969 10.2174/138161212802083707 10.1016/j.chroma.2010.12.041 10.1186/s40169-017-0153-6 10.1016/j.canlet.2019.04.009 10.1016/j.talanta.2020.121679 10.1186/s40170-020-00237-2 10.3390/nu7042930 10.1038/s41575-019-0186-y |
| ContentType | Journal Article |
| Copyright | 2022 |
| Copyright_xml | – notice: 2022 |
| DBID | AAYXX CITATION 7S9 L.6 |
| DOI | 10.1016/j.chroma.2022.463504 |
| DatabaseName | CrossRef AGRICOLA AGRICOLA - Academic |
| DatabaseTitle | CrossRef AGRICOLA AGRICOLA - Academic |
| DatabaseTitleList | AGRICOLA |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Chemistry |
| ExternalDocumentID | 10_1016_j_chroma_2022_463504 S0021967322006963 |
| GroupedDBID | --- --K --M -~X .~1 0R~ 1B1 1RT 1~. 1~5 4.4 457 4G. 53G 5GY 5RE 5VS 7-5 71M 8P~ 9JN AABNK AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AARLI AAXUO ABFNM ABFRF ABJNI ABMAC ABYKQ ACDAQ ACGFO ACGFS ACRLP ADBBV ADECG ADEZE AEBSH AEFWE AEKER AENEX AFKWA AFTJW AFZHZ AGHFR AGUBO AGYEJ AHHHB AIEXJ AIKHN AITUG AJOXV AJSZI ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ AXJTR BKOJK BLXMC DU5 EBS EFJIC EFLBG EO8 EO9 EP2 EP3 F5P FDB FLBIZ FNPLU FYGXN G-Q GBLVA IH2 IHE J1W KOM M36 M41 MO0 N9A O-L O9- OAUVE OZT P-8 P-9 P2P PC. Q38 ROL RPZ SCC SCH SDF SDG SDP SES SPC SPCBC SSK SSZ T5K WH7 XPP YK3 ZMT ~02 ~G- ~KM .GJ 29K AAHBH AATTM AAXKI AAYJJ AAYWO AAYXX ABDPE ABXDB ACNNM ACVFH ADCNI AEIPS AEUPX AFJKZ AFPUW AFXIZ AGCQF AGRNS AI. AIGII AIIUN AJQLL AKBMS AKRWK AKYEP ANKPU APXCP ASPBG AVWKF AZFZN BNPGV CITATION D-I EJD FEDTE FGOYB HMU HVGLF HZ~ H~9 OHT RIG SCB SEW SSH UQL VH1 WUQ ZGI ZKB ZXP 7S9 L.6 |
| ID | FETCH-LOGICAL-c287t-2932b3aca3b0006b3c5d05bbd3428bf61a33cca4cccdeb37cbc79defd256f4723 |
| IEDL.DBID | .~1 |
| ISSN | 0021-9673 |
| IngestDate | Fri Jul 11 02:48:01 EDT 2025 Thu Apr 24 23:09:24 EDT 2025 Tue Jul 01 02:39:05 EDT 2025 Fri Feb 23 02:36:22 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | DEABA LLOQ Hepatocellular carcinoma MRM UDCA Derivatization GCDCA MDCA ANOVA BLDA HOBt FA 20:2-n6 ESI HATU CDCA PGE2 RSD DCA GCA HPLC-MS OPLS-DA HCC GHDCA RSM COX RE HDCA Carboxyl submetabolome |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c287t-2932b3aca3b0006b3c5d05bbd3428bf61a33cca4cccdeb37cbc79defd256f4723 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0003-3087-4692 |
| PQID | 2723125606 |
| PQPubID | 24069 |
| ParticipantIDs | proquest_miscellaneous_2723125606 crossref_primary_10_1016_j_chroma_2022_463504 crossref_citationtrail_10_1016_j_chroma_2022_463504 elsevier_sciencedirect_doi_10_1016_j_chroma_2022_463504 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2022-11-08 |
| PublicationDateYYYYMMDD | 2022-11-08 |
| PublicationDate_xml | – month: 11 year: 2022 text: 2022-11-08 day: 08 |
| PublicationDecade | 2020 |
| PublicationTitle | Journal of Chromatography A |
| PublicationYear | 2022 |
| Publisher | Elsevier B.V |
| Publisher_xml | – name: Elsevier B.V |
| References | Cevasco, Piatek, Scapolla, Thea (bib0028) 2011; 1218 Kanemitsu, Mishima, Maekawa, Matsumoto, Saigusa, Yamaguchi, Ogura, Tsukamoto, Tomioka, Abe, Mano (bib0031) 2019; 9 Lin, Ding, Wang, Wang, Yin, Yan, Zhang, Yang, Shen (bib0039) 2017; 66 Mehta, Prabhakar, Kumar, Deshmukh, Sharma (bib0005) 2013; 698 Shi, Yang, Hu, Liao, Qiao, Shen, Xie, Zhu (bib0049) 2020; 12 Bartolomaeus, Balogh, Yakoub, Homann, Marko, Hoges, Tsvetkov, Krannich, Wundersitz, Avery, Haase, Kraker, Hering, Maase, Kusche-Vihrog, Grandoch, Fielitz, Kempa, Gollasch, Zhumadilov, Kozhakhmetov, Kushugulova, Eckardt, Dechend, Rump, Forslund, Muller, Stegbauer, Wilck (bib0003) 2019; 139 Saponaro, Gaggini, Carli, Gastaldelli (bib0034) 2015; 7 Yang, Hainaut, Gores, Amadou, Plymoth, Roberts (bib0011) 2019; 16 Hanna, Hafez (bib0006) 2018; 11 Xu, Zheng, Cao, Li, Liu (bib0040) 2018; 37 Dong, Li, Xiu, Dong, Xu, Zhai, Liu, Jiang, Sun, Li, Qiao (bib0045) 2014; 9 Schaap, Trauner, Jansen (bib0009) 2014; 11 Xia, He, Ren, Xu, Wan (bib0029) 2020; 1120 Zhang, Su, Qi, Liu, Zhang, Zhong, Xu, Liu, Hu, Chen, Zhang, Cai (bib0025) 2021; 222 Qin, Su, Yu, Kojima (bib0037) 2020; 11 Cheng, Xiong, Wang, Yuan, Feng (bib0020) 2018; 29 Ye, Jiang, Lu, Wen, Yang (bib0027) 2020; 1618 Zhang, Sun, Yan, Han, Ye, Wang (bib0046) 2013; 418 Thomas, Luu, Wang, Xie, Adams-Haduch, Jin, Koh, Jia, Behari, Yuan (bib0047) 2021; 13 Zarate, El Jaber-Vazdekis, Tejera, Perez, Rodriguez (bib0004) 2017; 6 Nagarajan, Butler, Hoy (bib0014) 2021; 9 Chen, Sun, Khalsa, Bailey, Kelleher, Spees, Zhu (bib0030) 2021; 200 Gao, Lv, Li, Liu, Zong, Ye, Li, Yang, Jiang, Hou, Jing, Han, Wei (bib0048) 2019; 454 Hu, An, Shi, Li, Liu (bib0026) 2020; 178 Sun, Cai, Gonzalez (bib0015) 2021; 18 Yang, Zhong, Zhou, Zhou, Xiu, Liu, Wang, Li, Tang, Chen, Yao, Huang, Liu, Dong (bib0041) 2021; 28 Piccinin, Villani, Moschetta (bib0050) 2019; 16 He, Luo, Chen, Chen, Fu, Hou, Hu (bib0023) 2019; 569 Jia, Xie, Jia (bib0010) 2018; 15 Zhang, Xiao, Zhan, Yuan, Feng (bib0018) 2022; 33 Vriens, Christen, Parik, Broekaert, Yoshinaga, Talebi, Dehairs, Escalona-Noguero, Schmieder, Cornfield, Charlton, Romero-Perez, Rossi, Rinaldi, Orth, Boon, Kerstens, Kwan, Faubert, Mendez-Lucas, Kopitz, Chen, Fernandez-Garcia, Duarte, Schmitz, Steigemann, Najimi, Hagebarth, Van Ginderachter, Sokal, Gotoh, Wong, Verfaillie, Derua, Munck, Yuneva, Beretta, DeBerardinis, Swinnen, Hodson, Cassiman, Verslype, Christian, Grunewald, Grunewald, Fendt (bib0038) 2019; 566 Wang, Fan, Jiang, Qu (bib0043) 2013; 34 Ohira, Tsutsui, Fujioka (bib0002) 2017; 24 Yuan, Zhu, Guo, Zheng, Wang, Wang, Xu, Liu, He, Hu, Zheng, Xu, Feng (bib0017) 2018; 90 Fiorucci, Biagioli, Zampella, Distrutti (bib0008) 2018; 9 Zhao, Li (bib0022) 2018; 90 Calvisi, Wang, Ho, Ladu, Lee, Mattu, Destefanis, Delogu, Zimmermann, Ericsson, Brozzetti, Staniscia, Chen, Dombrowski, Evert (bib0033) 2011; 140 Sia, Hoshida, Villanueva, Roayaie, Ferrer, Tabak, Peix, Sole, Tovar, Alsinet, Cornella, Klotzle, Fan, Cotsoglou, Thung, Fuster, Waxman, Garcia-Valdecasas, Bruix, Schwartz, Beroukhim, Mazzaferro, Llovet (bib0052) 2013; 144 Chen, Gao, Wu, Shrestha, Imai, Uemura, Hirano, Chiba, Hui (bib0024) 2019; 1126-1127 Xie, Chen, Feng, Zuo, Zhao, Li (bib0036) 2021; 8 Zhao, Li (bib0021) 2020; 131 Chen, Zhang, Wang, Chen, Ling, Yang, Wang, Duan, Liu, Guo, Fang, Liu, Liu, Liu, Otkur, Qi, Liu, Xia, Liu, Piao (bib0035) 2021; 8 Neis, Dejong, Rensen (bib0001) 2015; 7 Bawazeer, Muhsen Ali, Alhawiti, Khalaf, Gibson, Tusiimire, Watson (bib0019) 2017; 166 Fishbein, Hammock, Serhan, Panigrahy (bib0016) 2021; 218 Fan, Sun, Ma, Zhong, Wei (bib0042) 2013; 55 Tai, Zhang, Gao, Zhao, Tong, Ye, Huang, Liu, Tang (bib0044) 2019; 11 Ma, Kesarwala, Eggert, Medina-Echeverz, Kleiner, Jin, Stroncek, Terabe, Kapoor, ElGindi, Han, Thornton, Zhang, Egger, Luo, Felsher, McVicar, Weber, Heikenwalder, Greten (bib0032) 2016; 531 van der Windt, Sud, Zhang, Varley, Goswami, Yazdani, Tohme, Loughran, O'Doherty, Minervini, Huang, Simmons, Tsung (bib0051) 2018; 68 Bertuccio, Turati, Carioli, Rodriguez, Vecchia, Malvezzi, Negri (bib0013) 2017; 67 Ferlay, Colombet, Soerjomataram, Parkin, Pineros, Znaor, Bray (bib0012) 2021 Vendramini-Costa, Carvalho (bib0007) 2012; 18 Piccinin (10.1016/j.chroma.2022.463504_bib0050) 2019; 16 Neis (10.1016/j.chroma.2022.463504_bib0001) 2015; 7 Vendramini-Costa (10.1016/j.chroma.2022.463504_bib0007) 2012; 18 Shi (10.1016/j.chroma.2022.463504_bib0049) 2020; 12 Zhao (10.1016/j.chroma.2022.463504_bib0021) 2020; 131 Cevasco (10.1016/j.chroma.2022.463504_bib0028) 2011; 1218 Lin (10.1016/j.chroma.2022.463504_bib0039) 2017; 66 Bertuccio (10.1016/j.chroma.2022.463504_bib0013) 2017; 67 Xu (10.1016/j.chroma.2022.463504_bib0040) 2018; 37 He (10.1016/j.chroma.2022.463504_bib0023) 2019; 569 Zhao (10.1016/j.chroma.2022.463504_bib0022) 2018; 90 Qin (10.1016/j.chroma.2022.463504_bib0037) 2020; 11 Kanemitsu (10.1016/j.chroma.2022.463504_bib0031) 2019; 9 Wang (10.1016/j.chroma.2022.463504_bib0043) 2013; 34 Calvisi (10.1016/j.chroma.2022.463504_bib0033) 2011; 140 Gao (10.1016/j.chroma.2022.463504_bib0048) 2019; 454 Ohira (10.1016/j.chroma.2022.463504_bib0002) 2017; 24 van der Windt (10.1016/j.chroma.2022.463504_bib0051) 2018; 68 Bawazeer (10.1016/j.chroma.2022.463504_bib0019) 2017; 166 Zarate (10.1016/j.chroma.2022.463504_bib0004) 2017; 6 Thomas (10.1016/j.chroma.2022.463504_bib0047) 2021; 13 Cheng (10.1016/j.chroma.2022.463504_bib0020) 2018; 29 Hu (10.1016/j.chroma.2022.463504_bib0026) 2020; 178 Chen (10.1016/j.chroma.2022.463504_bib0024) 2019; 1126-1127 Nagarajan (10.1016/j.chroma.2022.463504_bib0014) 2021; 9 Ye (10.1016/j.chroma.2022.463504_bib0027) 2020; 1618 Jia (10.1016/j.chroma.2022.463504_bib0010) 2018; 15 Xie (10.1016/j.chroma.2022.463504_bib0036) 2021; 8 Zhang (10.1016/j.chroma.2022.463504_bib0046) 2013; 418 Zhang (10.1016/j.chroma.2022.463504_bib0025) 2021; 222 Yang (10.1016/j.chroma.2022.463504_bib0041) 2021; 28 Chen (10.1016/j.chroma.2022.463504_bib0035) 2021; 8 Sia (10.1016/j.chroma.2022.463504_bib0052) 2013; 144 Chen (10.1016/j.chroma.2022.463504_bib0030) 2021; 200 Fan (10.1016/j.chroma.2022.463504_bib0042) 2013; 55 Xia (10.1016/j.chroma.2022.463504_bib0029) 2020; 1120 Dong (10.1016/j.chroma.2022.463504_bib0045) 2014; 9 Hanna (10.1016/j.chroma.2022.463504_bib0006) 2018; 11 Yang (10.1016/j.chroma.2022.463504_bib0011) 2019; 16 Ma (10.1016/j.chroma.2022.463504_bib0032) 2016; 531 Bartolomaeus (10.1016/j.chroma.2022.463504_bib0003) 2019; 139 Sun (10.1016/j.chroma.2022.463504_bib0015) 2021; 18 Mehta (10.1016/j.chroma.2022.463504_bib0005) 2013; 698 Fishbein (10.1016/j.chroma.2022.463504_bib0016) 2021; 218 Zhang (10.1016/j.chroma.2022.463504_bib0018) 2022; 33 Schaap (10.1016/j.chroma.2022.463504_bib0009) 2014; 11 Yuan (10.1016/j.chroma.2022.463504_bib0017) 2018; 90 Vriens (10.1016/j.chroma.2022.463504_bib0038) 2019; 566 Tai (10.1016/j.chroma.2022.463504_bib0044) 2019; 11 Ferlay (10.1016/j.chroma.2022.463504_bib0012) 2021 Saponaro (10.1016/j.chroma.2022.463504_bib0034) 2015; 7 Fiorucci (10.1016/j.chroma.2022.463504_bib0008) 2018; 9 |
| References_xml | – volume: 6 start-page: 25 year: 2017 ident: bib0004 article-title: Significance of long chain polyunsaturated fatty acids in human health publication-title: Clin. Transl. Med. – volume: 24 start-page: 660 year: 2017 end-page: 672 ident: bib0002 article-title: Are short chain fatty acids in gut microbiota defensive players for inflammation and atherosclerosis? publication-title: J. Atheroscler. Thromb. – volume: 67 start-page: 302 year: 2017 end-page: 309 ident: bib0013 article-title: Global trends and predictions in hepatocellular carcinoma mortality publication-title: J. Hepatol. – volume: 566 start-page: 403 year: 2019 end-page: 406 ident: bib0038 article-title: Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity publication-title: Nature – volume: 8 year: 2021 ident: bib0035 article-title: Identification and characterization of robust hepatocellular carcinoma prognostic subtypes based on an integrative metabolite-protein interaction network publication-title: Adv. Sci. – volume: 18 start-page: 3831 year: 2012 end-page: 3852 ident: bib0007 article-title: Molecular link mechanisms between inflammation and cancer publication-title: Curr. Pharm. Des. – volume: 418 start-page: 86 year: 2013 end-page: 90 ident: bib0046 article-title: Urinary metabolic profiling identifies a key role for glycocholic acid in human liver cancer by ultra-performance liquid-chromatography coupled with high-definition mass spectrometry publication-title: Clin. Chim. Acta – volume: 200 year: 2021 ident: bib0030 article-title: Accurate and reliable quantitation of short chain fatty acids from human feces by ultra high-performance liquid chromatography-high resolution mass spectrometry (UPLC-HRMS) publication-title: J. Pharm. Biomed. Anal. – volume: 140 start-page: 1071 year: 2011 end-page: 1083 ident: bib0033 article-title: Increased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma publication-title: Gastroenterology – volume: 18 start-page: 335 year: 2021 end-page: 347 ident: bib0015 article-title: The role of farnesoid X receptor in metabolic diseases, and gastrointestinal and liver cancer publication-title: Nat. Rev. Gastroenterol. Hepatol. – volume: 9 start-page: 19075 year: 2019 ident: bib0031 article-title: Comprehensive and semi-quantitative analysis of carboxyl-containing metabolites related to gut microbiota on chronic kidney disease using 2-picolylamine isotopic labeling LC-MS/MS publication-title: Sci. Rep. – volume: 218 year: 2021 ident: bib0016 article-title: Carcinogenesis: failure of resolution of inflammation? publication-title: Pharmacol. Ther. – volume: 90 start-page: 3512 year: 2018 end-page: 3520 ident: bib0017 article-title: Comprehensive profiling of fecal metabolome of mice by integrated chemical isotope labeling-mass spectrometry analysis publication-title: Anal. Chem. – volume: 11 start-page: 55 year: 2014 end-page: 67 ident: bib0009 article-title: Bile acid receptors as targets for drug development publication-title: Nat. Rev. Gastroenterol. Hepatol. – volume: 16 start-page: 160 year: 2019 end-page: 174 ident: bib0050 article-title: Metabolic aspects in NAFLD, NASH and hepatocellular carcinoma: the role of PGC1 coactivators publication-title: Nat. Rev. Gastroenterol. Hepatol. – volume: 1120 start-page: 24 year: 2020 end-page: 35 ident: bib0029 article-title: Quantitative profiling of eicosanoids derived from n-6 and n-3 polyunsaturated fatty acids by twin derivatization strategy combined with LC-MS/MS in patients with type 2 diabetes mellitus publication-title: Anal. Chim. Acta – volume: 11 start-page: 2831 year: 2019 end-page: 2848 ident: bib0044 article-title: Suppressing growth and invasion of human hepatocellular carcinoma cells by celecoxib through inhibition of cyclooxygenase-2 publication-title: Cancer Manag. Res. – volume: 178 year: 2020 ident: bib0026 article-title: A sensitive and efficient method for simultaneous profiling of bile acids and fatty acids by UPLC-MS/MS publication-title: J. Pharm. Biomed. Anal. – volume: 1218 start-page: 787 year: 2011 end-page: 792 ident: bib0028 article-title: A simple, sensitive and efficient assay for the determination of publication-title: J. Chromatogr. A – volume: 569 start-page: 1 year: 2019 end-page: 9 ident: bib0023 article-title: Profiling of carboxyl-containing metabolites in smokers and non-smokers by stable isotope labeling combined with LC-MS/MS publication-title: Anal. Biochem. – volume: 7 start-page: 2930 year: 2015 end-page: 2946 ident: bib0001 article-title: The role of microbial amino acid metabolism in host metabolism publication-title: Nutrients – volume: 139 start-page: 1407 year: 2019 end-page: 1421 ident: bib0003 article-title: Short-chain fatty acid propionate protects from hypertensive cardiovascular damage publication-title: Circulation – volume: 9 start-page: 2 year: 2021 ident: bib0014 article-title: The diversity and breadth of cancer cell fatty acid metabolism publication-title: Cancer Metab. – volume: 454 start-page: 215 year: 2019 end-page: 223 ident: bib0048 article-title: Glycochenodeoxycholate promotes hepatocellular carcinoma invasion and migration by AMPK/mTOR dependent autophagy activation publication-title: Cancer Lett. – volume: 698 start-page: 6 year: 2013 end-page: 18 ident: bib0005 article-title: Excitotoxicity: bridge to various triggers in neurodegenerative disorders publication-title: Eur. J. Pharmacol. – year: 2021 ident: bib0012 article-title: Cancer statistics for the year 2020: an overview publication-title: Int. J. Cancer – volume: 144 start-page: 829 year: 2013 end-page: 840 ident: bib0052 article-title: Integrative molecular analysis of intrahepatic cholangiocarcinoma reveals 2 classes that have different outcomes publication-title: Gastroenterology – volume: 11 start-page: 23 year: 2018 end-page: 32 ident: bib0006 article-title: Synopsis of arachidonic acid metabolism: a review publication-title: J. Adv. Res. – volume: 7 start-page: 9453 year: 2015 end-page: 9474 ident: bib0034 article-title: The subtle balance between lipolysis and lipogenesis: a critical point in metabolic homeostasis publication-title: Nutrients – volume: 33 start-page: 4746 year: 2022 end-page: 4749 ident: bib0018 article-title: Simultaneous determination of indole metabolites of tryptophan in rat feces by chemical labeling assisted liquid chromatography-tandem mass spectrometry publication-title: Chin. Chem. Lett. – volume: 222 year: 2021 ident: bib0025 article-title: Metabolomic profiling of fatty acid biomarkers for intracerebral hemorrhage stroke publication-title: Talanta – volume: 13 start-page: 2648 year: 2021 ident: bib0047 article-title: Association between pre-diagnostic serum bile acids and hepatocellular carcinoma: the singapore chinese health study publication-title: Cancers – volume: 1618 year: 2020 ident: bib0027 article-title: Quantification of prostaglandins in rat uterus by ultra high-performance liquid chromatography/mass spectrometry based on derivatization with analogous reagents publication-title: J. Chromatogr. A – volume: 166 start-page: 75 year: 2017 end-page: 80 ident: bib0019 article-title: A method for the analysis of sugars in biological systems using reductive amination in combination with hydrophilic interaction chromatography and high resolution mass spectrometry publication-title: Talanta – volume: 16 start-page: 589 year: 2019 end-page: 604 ident: bib0011 article-title: A global view of hepatocellular carcinoma: trends, risk, prevention and management publication-title: Nat. Rev. Gastroenterol. Hepatol. – volume: 29 start-page: 115 year: 2018 end-page: 118 ident: bib0020 article-title: Chiral derivatization coupled with liquid chromatography/mass spectrometry for determining ketone metabolites of hydroxybutyrate enantiomers publication-title: Chin. Chem. Lett. – volume: 37 start-page: 269 year: 2018 end-page: 277 ident: bib0040 article-title: Bioanalytical insights into the association between eicosanoids and pathogenesis of hepatocellular carcinoma publication-title: Cancer Metastasis Rev. – volume: 55 start-page: 174 year: 2013 end-page: 183 ident: bib0042 article-title: Melatonin overcomes apoptosis resistance in human hepatocellular carcinoma by targeting survivin and XIAP publication-title: J. Pineal Res. – volume: 11 start-page: 66 year: 2020 ident: bib0037 article-title: Lipid desaturation-associated endoplasmic reticulum stress regulates MYCN gene expression in hepatocellular carcinoma cells publication-title: Cell Death Dis. – volume: 66 start-page: 432 year: 2017 end-page: 448 ident: bib0039 article-title: Functional lipidomics: palmitic acid impairs hepatocellular carcinoma development by modulating membrane fluidity and glucose metabolism publication-title: Hepatology – volume: 15 start-page: 111 year: 2018 end-page: 128 ident: bib0010 article-title: Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis publication-title: Nat. Rev. Gastroenterol. Hepatol. – volume: 28 start-page: 844 year: 2021 end-page: 855 ident: bib0041 article-title: Targeting of the COX-2/PGE2 axis enhances the antitumor activity of T7 peptide publication-title: Drug Deliv. – volume: 90 start-page: 13514 year: 2018 end-page: 13522 ident: bib0022 article-title: Dansylhydrazine isotope labeling LC-MS for comprehensive carboxylic acid submetabolome profiling publication-title: Anal. Chem. – volume: 34 start-page: 638 year: 2013 end-page: 646 ident: bib0043 article-title: Selective COX-2 inhibitor celecoxib induces epithelial-mesenchymal transition in human lung cancer cells via activating MEK-ERK signaling publication-title: Carcinogenesis – volume: 68 start-page: 1347 year: 2018 end-page: 1360 ident: bib0051 article-title: Neutrophil extracellular traps promote inflammation and development of hepatocellular carcinoma in nonalcoholic steatohepatitis publication-title: Hepatology – volume: 131 start-page: 115988 year: 2020 ident: bib0021 article-title: Chemical derivatization in LC-MS-based metabolomics study publication-title: TrAC Trends Anal. Chem. – volume: 531 start-page: 253 year: 2016 end-page: 257 ident: bib0032 article-title: NAFLD causes selective CD4(+) T lymphocyte loss and promotes hepatocarcinogenesis publication-title: Nature – volume: 8 start-page: 1623 year: 2021 end-page: 1641 ident: bib0036 article-title: Acyl-CoA thioesterase 7 is transcriptionally activated by kruppel-like factor 13 and promotes the progression of hepatocellular carcinoma publication-title: J. Hepatocell. Carcinoma – volume: 1126-1127 year: 2019 ident: bib0024 article-title: Development of a simultaneous quantitation for short-, medium-, long-, and very long-chain fatty acids in human plasma by 2-nitrophenylhydrazine-derivatization and liquid chromatography-tandem mass spectrometry publication-title: J. Chromatogr. B Anal. Technol. Biomed. Life Sci. – volume: 9 start-page: e92864 year: 2014 ident: bib0045 article-title: Meloxicam executes its antitumor effects against hepatocellular carcinoma in COX-2- dependent and -independent pathways publication-title: PLoS One – volume: 9 start-page: 1853 year: 2018 ident: bib0008 article-title: Bile acids activated receptors regulate innate immunity publication-title: Front. Immunol. – volume: 12 start-page: 15546 year: 2020 end-page: 15555 ident: bib0049 article-title: Glycochenodeoxycholic acid induces stemness and chemoresistance via the STAT3 signaling pathway in hepatocellular carcinoma cells publication-title: Aging – volume: 166 start-page: 75 year: 2017 ident: 10.1016/j.chroma.2022.463504_bib0019 article-title: A method for the analysis of sugars in biological systems using reductive amination in combination with hydrophilic interaction chromatography and high resolution mass spectrometry publication-title: Talanta doi: 10.1016/j.talanta.2017.01.038 – volume: 11 start-page: 66 year: 2020 ident: 10.1016/j.chroma.2022.463504_bib0037 article-title: Lipid desaturation-associated endoplasmic reticulum stress regulates MYCN gene expression in hepatocellular carcinoma cells publication-title: Cell Death Dis. doi: 10.1038/s41419-020-2257-y – volume: 9 start-page: 19075 year: 2019 ident: 10.1016/j.chroma.2022.463504_bib0031 article-title: Comprehensive and semi-quantitative analysis of carboxyl-containing metabolites related to gut microbiota on chronic kidney disease using 2-picolylamine isotopic labeling LC-MS/MS publication-title: Sci. Rep. doi: 10.1038/s41598-019-55600-1 – volume: 16 start-page: 160 year: 2019 ident: 10.1016/j.chroma.2022.463504_bib0050 article-title: Metabolic aspects in NAFLD, NASH and hepatocellular carcinoma: the role of PGC1 coactivators publication-title: Nat. Rev. Gastroenterol. Hepatol. doi: 10.1038/s41575-018-0089-3 – volume: 90 start-page: 3512 year: 2018 ident: 10.1016/j.chroma.2022.463504_bib0017 article-title: Comprehensive profiling of fecal metabolome of mice by integrated chemical isotope labeling-mass spectrometry analysis publication-title: Anal. Chem. doi: 10.1021/acs.analchem.7b05355 – volume: 178 year: 2020 ident: 10.1016/j.chroma.2022.463504_bib0026 article-title: A sensitive and efficient method for simultaneous profiling of bile acids and fatty acids by UPLC-MS/MS publication-title: J. Pharm. Biomed. Anal. doi: 10.1016/j.jpba.2019.112815 – volume: 140 start-page: 1071 year: 2011 ident: 10.1016/j.chroma.2022.463504_bib0033 article-title: Increased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma publication-title: Gastroenterology doi: 10.1053/j.gastro.2010.12.006 – year: 2021 ident: 10.1016/j.chroma.2022.463504_bib0012 article-title: Cancer statistics for the year 2020: an overview publication-title: Int. J. Cancer doi: 10.1002/ijc.33588 – volume: 68 start-page: 1347 year: 2018 ident: 10.1016/j.chroma.2022.463504_bib0051 article-title: Neutrophil extracellular traps promote inflammation and development of hepatocellular carcinoma in nonalcoholic steatohepatitis publication-title: Hepatology doi: 10.1002/hep.29914 – volume: 1120 start-page: 24 year: 2020 ident: 10.1016/j.chroma.2022.463504_bib0029 article-title: Quantitative profiling of eicosanoids derived from n-6 and n-3 polyunsaturated fatty acids by twin derivatization strategy combined with LC-MS/MS in patients with type 2 diabetes mellitus publication-title: Anal. Chim. Acta doi: 10.1016/j.aca.2020.04.064 – volume: 24 start-page: 660 year: 2017 ident: 10.1016/j.chroma.2022.463504_bib0002 article-title: Are short chain fatty acids in gut microbiota defensive players for inflammation and atherosclerosis? publication-title: J. Atheroscler. Thromb. doi: 10.5551/jat.RV17006 – volume: 9 start-page: 1853 year: 2018 ident: 10.1016/j.chroma.2022.463504_bib0008 article-title: Bile acids activated receptors regulate innate immunity publication-title: Front. Immunol. doi: 10.3389/fimmu.2018.01853 – volume: 218 year: 2021 ident: 10.1016/j.chroma.2022.463504_bib0016 article-title: Carcinogenesis: failure of resolution of inflammation? publication-title: Pharmacol. Ther. doi: 10.1016/j.pharmthera.2020.107670 – volume: 90 start-page: 13514 year: 2018 ident: 10.1016/j.chroma.2022.463504_bib0022 article-title: Dansylhydrazine isotope labeling LC-MS for comprehensive carboxylic acid submetabolome profiling publication-title: Anal. Chem. doi: 10.1021/acs.analchem.8b03435 – volume: 66 start-page: 432 year: 2017 ident: 10.1016/j.chroma.2022.463504_bib0039 article-title: Functional lipidomics: palmitic acid impairs hepatocellular carcinoma development by modulating membrane fluidity and glucose metabolism publication-title: Hepatology doi: 10.1002/hep.29033 – volume: 29 start-page: 115 year: 2018 ident: 10.1016/j.chroma.2022.463504_bib0020 article-title: Chiral derivatization coupled with liquid chromatography/mass spectrometry for determining ketone metabolites of hydroxybutyrate enantiomers publication-title: Chin. Chem. Lett. doi: 10.1016/j.cclet.2017.06.009 – volume: 131 start-page: 115988 year: 2020 ident: 10.1016/j.chroma.2022.463504_bib0021 article-title: Chemical derivatization in LC-MS-based metabolomics study publication-title: TrAC Trends Anal. Chem. doi: 10.1016/j.trac.2020.115988 – volume: 11 start-page: 23 year: 2018 ident: 10.1016/j.chroma.2022.463504_bib0006 article-title: Synopsis of arachidonic acid metabolism: a review publication-title: J. Adv. Res. doi: 10.1016/j.jare.2018.03.005 – volume: 418 start-page: 86 year: 2013 ident: 10.1016/j.chroma.2022.463504_bib0046 article-title: Urinary metabolic profiling identifies a key role for glycocholic acid in human liver cancer by ultra-performance liquid-chromatography coupled with high-definition mass spectrometry publication-title: Clin. Chim. Acta doi: 10.1016/j.cca.2012.12.024 – volume: 9 start-page: e92864 year: 2014 ident: 10.1016/j.chroma.2022.463504_bib0045 article-title: Meloxicam executes its antitumor effects against hepatocellular carcinoma in COX-2- dependent and -independent pathways publication-title: PLoS One doi: 10.1371/journal.pone.0092864 – volume: 8 year: 2021 ident: 10.1016/j.chroma.2022.463504_bib0035 article-title: Identification and characterization of robust hepatocellular carcinoma prognostic subtypes based on an integrative metabolite-protein interaction network publication-title: Adv. Sci. doi: 10.1002/advs.202100311 – volume: 15 start-page: 111 year: 2018 ident: 10.1016/j.chroma.2022.463504_bib0010 article-title: Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis publication-title: Nat. Rev. Gastroenterol. Hepatol. doi: 10.1038/nrgastro.2017.119 – volume: 11 start-page: 55 year: 2014 ident: 10.1016/j.chroma.2022.463504_bib0009 article-title: Bile acid receptors as targets for drug development publication-title: Nat. Rev. Gastroenterol. Hepatol. doi: 10.1038/nrgastro.2013.151 – volume: 28 start-page: 844 year: 2021 ident: 10.1016/j.chroma.2022.463504_bib0041 article-title: Targeting of the COX-2/PGE2 axis enhances the antitumor activity of T7 peptide in vitro and in vivo publication-title: Drug Deliv. doi: 10.1080/10717544.2021.1914776 – volume: 55 start-page: 174 year: 2013 ident: 10.1016/j.chroma.2022.463504_bib0042 article-title: Melatonin overcomes apoptosis resistance in human hepatocellular carcinoma by targeting survivin and XIAP publication-title: J. Pineal Res. doi: 10.1111/jpi.12060 – volume: 13 start-page: 2648 year: 2021 ident: 10.1016/j.chroma.2022.463504_bib0047 article-title: Association between pre-diagnostic serum bile acids and hepatocellular carcinoma: the singapore chinese health study publication-title: Cancers doi: 10.3390/cancers13112648 – volume: 37 start-page: 269 year: 2018 ident: 10.1016/j.chroma.2022.463504_bib0040 article-title: Bioanalytical insights into the association between eicosanoids and pathogenesis of hepatocellular carcinoma publication-title: Cancer Metastasis Rev. doi: 10.1007/s10555-018-9747-8 – volume: 18 start-page: 335 year: 2021 ident: 10.1016/j.chroma.2022.463504_bib0015 article-title: The role of farnesoid X receptor in metabolic diseases, and gastrointestinal and liver cancer publication-title: Nat. Rev. Gastroenterol. Hepatol. doi: 10.1038/s41575-020-00404-2 – volume: 200 year: 2021 ident: 10.1016/j.chroma.2022.463504_bib0030 article-title: Accurate and reliable quantitation of short chain fatty acids from human feces by ultra high-performance liquid chromatography-high resolution mass spectrometry (UPLC-HRMS) publication-title: J. Pharm. Biomed. Anal. doi: 10.1016/j.jpba.2021.114066 – volume: 1126-1127 year: 2019 ident: 10.1016/j.chroma.2022.463504_bib0024 article-title: Development of a simultaneous quantitation for short-, medium-, long-, and very long-chain fatty acids in human plasma by 2-nitrophenylhydrazine-derivatization and liquid chromatography-tandem mass spectrometry publication-title: J. Chromatogr. B Anal. Technol. Biomed. Life Sci. doi: 10.1016/j.jchromb.2019.121771 – volume: 566 start-page: 403 year: 2019 ident: 10.1016/j.chroma.2022.463504_bib0038 article-title: Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity publication-title: Nature doi: 10.1038/s41586-019-0904-1 – volume: 34 start-page: 638 year: 2013 ident: 10.1016/j.chroma.2022.463504_bib0043 article-title: Selective COX-2 inhibitor celecoxib induces epithelial-mesenchymal transition in human lung cancer cells via activating MEK-ERK signaling publication-title: Carcinogenesis doi: 10.1093/carcin/bgs367 – volume: 1618 year: 2020 ident: 10.1016/j.chroma.2022.463504_bib0027 article-title: Quantification of prostaglandins in rat uterus by ultra high-performance liquid chromatography/mass spectrometry based on derivatization with analogous reagents publication-title: J. Chromatogr. A doi: 10.1016/j.chroma.2020.460869 – volume: 139 start-page: 1407 year: 2019 ident: 10.1016/j.chroma.2022.463504_bib0003 article-title: Short-chain fatty acid propionate protects from hypertensive cardiovascular damage publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.118.036652 – volume: 144 start-page: 829 year: 2013 ident: 10.1016/j.chroma.2022.463504_bib0052 article-title: Integrative molecular analysis of intrahepatic cholangiocarcinoma reveals 2 classes that have different outcomes publication-title: Gastroenterology doi: 10.1053/j.gastro.2013.01.001 – volume: 8 start-page: 1623 year: 2021 ident: 10.1016/j.chroma.2022.463504_bib0036 article-title: Acyl-CoA thioesterase 7 is transcriptionally activated by kruppel-like factor 13 and promotes the progression of hepatocellular carcinoma publication-title: J. Hepatocell. Carcinoma doi: 10.2147/JHC.S338353 – volume: 11 start-page: 2831 year: 2019 ident: 10.1016/j.chroma.2022.463504_bib0044 article-title: Suppressing growth and invasion of human hepatocellular carcinoma cells by celecoxib through inhibition of cyclooxygenase-2 publication-title: Cancer Manag. Res. doi: 10.2147/CMAR.S183376 – volume: 12 start-page: 15546 year: 2020 ident: 10.1016/j.chroma.2022.463504_bib0049 article-title: Glycochenodeoxycholic acid induces stemness and chemoresistance via the STAT3 signaling pathway in hepatocellular carcinoma cells publication-title: Aging doi: 10.18632/aging.103751 – volume: 698 start-page: 6 year: 2013 ident: 10.1016/j.chroma.2022.463504_bib0005 article-title: Excitotoxicity: bridge to various triggers in neurodegenerative disorders publication-title: Eur. J. Pharmacol. doi: 10.1016/j.ejphar.2012.10.032 – volume: 7 start-page: 9453 year: 2015 ident: 10.1016/j.chroma.2022.463504_bib0034 article-title: The subtle balance between lipolysis and lipogenesis: a critical point in metabolic homeostasis publication-title: Nutrients doi: 10.3390/nu7115475 – volume: 67 start-page: 302 year: 2017 ident: 10.1016/j.chroma.2022.463504_bib0013 article-title: Global trends and predictions in hepatocellular carcinoma mortality publication-title: J. Hepatol. doi: 10.1016/j.jhep.2017.03.011 – volume: 569 start-page: 1 year: 2019 ident: 10.1016/j.chroma.2022.463504_bib0023 article-title: Profiling of carboxyl-containing metabolites in smokers and non-smokers by stable isotope labeling combined with LC-MS/MS publication-title: Anal. Biochem. doi: 10.1016/j.ab.2018.12.006 – volume: 33 start-page: 4746 year: 2022 ident: 10.1016/j.chroma.2022.463504_bib0018 article-title: Simultaneous determination of indole metabolites of tryptophan in rat feces by chemical labeling assisted liquid chromatography-tandem mass spectrometry publication-title: Chin. Chem. Lett. doi: 10.1016/j.cclet.2022.01.004 – volume: 531 start-page: 253 year: 2016 ident: 10.1016/j.chroma.2022.463504_bib0032 article-title: NAFLD causes selective CD4(+) T lymphocyte loss and promotes hepatocarcinogenesis publication-title: Nature doi: 10.1038/nature16969 – volume: 18 start-page: 3831 year: 2012 ident: 10.1016/j.chroma.2022.463504_bib0007 article-title: Molecular link mechanisms between inflammation and cancer publication-title: Curr. Pharm. Des. doi: 10.2174/138161212802083707 – volume: 1218 start-page: 787 year: 2011 ident: 10.1016/j.chroma.2022.463504_bib0028 article-title: A simple, sensitive and efficient assay for the determination of d- and l-lactic acid enantiomers in human plasma by high-performance liquid chromatography publication-title: J. Chromatogr. A doi: 10.1016/j.chroma.2010.12.041 – volume: 6 start-page: 25 year: 2017 ident: 10.1016/j.chroma.2022.463504_bib0004 article-title: Significance of long chain polyunsaturated fatty acids in human health publication-title: Clin. Transl. Med. doi: 10.1186/s40169-017-0153-6 – volume: 454 start-page: 215 year: 2019 ident: 10.1016/j.chroma.2022.463504_bib0048 article-title: Glycochenodeoxycholate promotes hepatocellular carcinoma invasion and migration by AMPK/mTOR dependent autophagy activation publication-title: Cancer Lett. doi: 10.1016/j.canlet.2019.04.009 – volume: 222 year: 2021 ident: 10.1016/j.chroma.2022.463504_bib0025 article-title: Metabolomic profiling of fatty acid biomarkers for intracerebral hemorrhage stroke publication-title: Talanta doi: 10.1016/j.talanta.2020.121679 – volume: 9 start-page: 2 year: 2021 ident: 10.1016/j.chroma.2022.463504_bib0014 article-title: The diversity and breadth of cancer cell fatty acid metabolism publication-title: Cancer Metab. doi: 10.1186/s40170-020-00237-2 – volume: 7 start-page: 2930 year: 2015 ident: 10.1016/j.chroma.2022.463504_bib0001 article-title: The role of microbial amino acid metabolism in host metabolism publication-title: Nutrients doi: 10.3390/nu7042930 – volume: 16 start-page: 589 year: 2019 ident: 10.1016/j.chroma.2022.463504_bib0011 article-title: A global view of hepatocellular carcinoma: trends, risk, prevention and management publication-title: Nat. Rev. Gastroenterol. Hepatol. doi: 10.1038/s41575-019-0186-y |
| SSID | ssj0017072 ssj0029838 |
| Score | 2.412636 |
| Snippet | •A convenient and efficient workflow for absolute quantification of carboxyl submetabolome was established based on the DEABA-labeled... Recent studies have shown that dysregulation of carboxyl submetabolome homeostasis is closely related to the occurrence and development of hepatocellular... |
| SourceID | proquest crossref elsevier |
| SourceType | Aggregation Database Enrichment Source Index Database Publisher |
| StartPage | 463504 |
| SubjectTerms | ambient temperature analysis of variance Bayesian theory biomarkers Carboxyl submetabolome chemical species chromatography Derivatization discriminant analysis Hepatocellular carcinoma hepatoma homeostasis humans metabolites pathogenesis response surface methodology species diversity |
| Title | A convenient and efficient 4-(diethylamino)-butylamine-labeled polarity-response-homodispersed strategy for absolute quantification of carboxyl submetabolome: Monitoring the whole progressive course of hepatocellular carcinoma |
| URI | https://dx.doi.org/10.1016/j.chroma.2022.463504 https://www.proquest.com/docview/2723125606 |
| Volume | 1683 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lj9MwELZWywEuiKdYHisjcYCDd5s4T25VxapQsQfEir1F9mSidtXGpU2BvfBj-SXM2EklENJKnNo0teVmvsyM02--EeJVAblNMwSlMUKV5E2kCsRU2QjKxFiAyOtsfzzPphfJh8v08kBMhloYplX2vj_4dO-t-09O-6t5ul4suMaX7rYsJ0Sy3G7Gip-sXkeYPvm5p3lE-Sjf60nFZaGDa2ZeAg0dauk84QvmG-eliOL4JKE43Pdu-0es-str-1B0dk_c7XNIOQ7LvC8OsH0gbk-G1m0Pxa-xDGxyLnaUpq0leqUIPkrU63qBZB6CwqJ1b5TddeE9KkIERaFarnm_S-m52gQGLaq5W7l6wariWzq_DZK215IyXmmshy_KrzsTmEfe2NI1EszGuh_XS7nlqNsR3pZuhW9lcCT8RFFS_im_c49e6ZliTMr9hrR65pbwFHMKl53jvxeYL8szAq16ZR6Ji7N3nydT1TdzUECbsk5RWhFbbcBon-dYDWk9Sq2tNW2AbJNFRmtCUwIANW3wc7CQlzU2NeVkTZLH-rE4bF2LT4QsISrRkmmbgs5EpR2VYDCBOLZp0WT6SOjBbBX0SufccGNZDZS2qyoYu2JjV8HYR0LtR62D0scN388HRFR_ILaiYHTDyJcDgCoCBl9C06LbbauYfmfESWj29L9nfybu8JGvlyyei8Nus8MXlDh19tjfGcfi1vj9bHrOr7NPX2a_AaG2Ih0 |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LbxMxELZKeiiXiqco5WEkDnAwza73yS2KqFLa5tRKvVn2rFdJlaxDsgH6d_klzNi7kUBIlbglcWw5O9_OjLPffMPY-wJyk2YWhLSRFUleR6KwNhUmgjLRBiDyOtuX02xynXy9SW_22LivhSFaZef7g0_33rr75KS7mier-ZxqfPFuy3JEJMntZvIB2yd1qmTA9kdn55Pp7mFCPsx3klJxWcjgnYmagLP7cjrP-YLZ2nk1ojj-lGAo7tq3_SNc_eW4fTQ6fcQOuzSSj8JOH7M92zxhB-O-e9tT9mvEA6Gc6h25bipuvVgEvUvEh2pu0UKIhnnjPgqzbcNrKxAUGIgqvqIjL2boYh1ItFbM3NJVcxIW3-D4Jqja3nFMerk2HsGWf9vqQD7y9uau5qDXxv28W_ANBd4WIbdwS_uZB19CfypyTEH5D2rTyz1ZjHi53y3unugltMQMI2br6AkDUWZpRcBdL_Uzdn365Wo8EV0_BwF4LmsFZhaxkRq09KmOkZBWw9SYSuIZyNRZpKVEQCUAUOEZPwcDeVnZusK0rE7yWD5ng8Y19gXjJUSlNWjausCRqDTDErRNII5NWtSZPGKyN5uCTuycem4sVM9qu1XB2IqMrYKxj5jYzVoFsY97vp_3iFB_gFZhPLpn5rseQAqBQZdQN9ZtNyrG3xlRHpq9_O_V37KDydXlhbo4m54fs4c04ssni1ds0K639jXmUa15090nvwFUOCMr |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+convenient+and+efficient+4-%28diethylamino%29-butylamine-labeled+polarity-response-homodispersed+strategy+for+absolute+quantification+of+carboxyl+submetabolome%3A+Monitoring+the+whole+progressive+course+of+hepatocellular+carcinoma&rft.jtitle=Journal+of+Chromatography+A&rft.au=Tong%2C+Minghui&rft.au=Zhang%2C+Qian&rft.au=Zhang%2C+Yiwen&rft.au=Xing%2C+Luwen&rft.date=2022-11-08&rft.pub=Elsevier+B.V&rft.issn=0021-9673&rft.volume=1683&rft_id=info:doi/10.1016%2Fj.chroma.2022.463504&rft.externalDocID=S0021967322006963 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0021-9673&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0021-9673&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0021-9673&client=summon |