Multiclinic controlled trial of bethanidine and guanethidine in severe hypertension

• Published in: Circulation (New York, N.Y.) Vol. 55; no. 3; pp. 519 - 525
• Main Authors: Ramirez, E A, Elson, L, Gear, A S, Oster, J R, Talmers, F N, Thomas, J R
• Format: Journal Article
• Language: English
• Published: United States 01.03.1977
• Subjects: Bethanidine - administration & dosage; Bethanidine - therapeutic use; Clinical Trials as Topic; Guanethidine - administration & dosage; Guanethidine - therapeutic use; Guanidines - therapeutic use; Humans; Hydrochlorothiazide - therapeutic use; Hypertension - drug therapy; Male; Middle Aged; Time Factors

One hundred and eight patients with initial diastolic blood pressure in the range of 100-124 mm Hg while taking hydrochlorothiazide were assigned randomly and double-blind to hydrochlorothiazide plus either bethanidine or guanethidine. The average reduction of the fifth and sixth months' diasto...