Gender Differences in 1,25 Dihydroxyvitamin D3 Immunomodulatory Effects in Multiple Sclerosis Patients and Healthy Subjects

• Published in: The Journal of immunology (1950) Vol. 185; no. 8; pp. 4948 - 4958
• Main Authors: Correale, Jorge, Ysrraelit, María C, Gaitán, María I
• Format: Journal Article
• Language: English
• Published: United States 15.10.2010
• Subjects: Adult; Calcitriol - blood; Calcitriol - metabolism; Calcitriol - pharmacology; Cell Proliferation - drug effects; Cytokines - biosynthesis; Enzyme-Linked Immunosorbent Assay; Estradiol - pharmacology; Estrogens - pharmacology; Female; Humans; Immunologic Factors - blood; Immunologic Factors - metabolism; Immunologic Factors - pharmacology; Male; Multiple Sclerosis, Relapsing-Remitting - immunology; Multiple Sclerosis, Relapsing-Remitting - metabolism; Receptors, Estrogen - metabolism; Reverse Transcriptase Polymerase Chain Reaction; Sex Characteristics; T-Lymphocytes - drug effects; T-Lymphocytes - immunology

Vitamin D3 is best known as a calcium homeostasis modulator; however, it also has immune-modulating potential. In this study, we demonstrated that immunomodulatory effects of vitamin D3 are significantly stronger in females than in males in multiple sclerosis patients, as well as in healthy subjects...