Premature ovarian insufficiency as a consequence of immunological abnormalities and dyslipidemia: a Mendelian randomization study

• Published in: Gynecological endocrinology Vol. 41; no. 1; p. 2541647
• Main Authors: Shao, Fengping, Li, Yinguang
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis Group 01.12.2025
• Subjects: Case-Control Studies; CD4-Positive T-Lymphocytes - metabolism; Dyslipidemias - blood; Dyslipidemias - genetics; Dyslipidemias - immunology; Female; Humans; immune cell traits; lipid metabolism; Lipid Metabolism - genetics; Lipid Metabolism - immunology; Lipoproteins, IDL - blood; Lipoproteins, IDL - genetics; Lipoproteins, IDL - immunology; Lipoproteins, LDL - blood; Lipoproteins, LDL - genetics; Lipoproteins, LDL - immunology; mendelian randomization; Mendelian Randomization Analysis; premature ovarian insufficiency; Primary Ovarian Insufficiency - blood; Primary Ovarian Insufficiency - genetics; Primary Ovarian Insufficiency - immunology; Proportional Hazards Models; Sialic Acid Binding Ig-like Lectin 3 - blood; Sialic Acid Binding Ig-like Lectin 3 - genetics; Sialic Acid Binding Ig-like Lectin 3 - immunology; T-Lymphocytes, Regulatory - immunology; T-Lymphocytes, Regulatory - metabolism; immune cell traits; premature ovarian insufficiency; mendelian randomization; lipid metabolism

Observational studies have suggested associations between premature ovarian insufficiency (POI) and immunological abnormalities or dyslipidemia, but causal evidence remains unestablished. We conducted a two-sample Mendelian randomization (MR) study to evaluate causal relationships of POI with immune...