Insights into FGFR4 (rs351855 and rs7708357) Gene Variants, Ki-67 and p53 in Pituitary Adenoma Pathophysiology

• Published in: International journal of molecular sciences Vol. 26; no. 15; p. 7565
• Main Authors: Juskiene, Martyna, Duseikaite, Monika, Vilkeviciute, Alvita, Karinauske, Egle, Baikstiene, Ieva, Makstiene, Jurgita, Poskiene, Lina, Tamasauskas, Arimantas, Liutkeviciene, Rasa, Verkauskiene, Rasa, Zilaitiene, Birute
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 05.08.2025; MDPI
• Subjects: Adenoma - genetics; Adenoma - metabolism; Adenoma - pathology; Adenoma - physiopathology; Adult; Aged; Alleles; Case-Control Studies; Cell cycle; Female; Females; Genetic Predisposition to Disease; Genotype; Humans; Ki-67 Antigen - genetics; Ki-67 Antigen - metabolism; Male; Males; Middle Aged; Pituitary Neoplasms - genetics; Pituitary Neoplasms - metabolism; Pituitary Neoplasms - pathology; Pituitary Neoplasms - physiopathology; Polymorphism, Single Nucleotide; Proteins; Receptor, Fibroblast Growth Factor, Type 4 - blood; Receptor, Fibroblast Growth Factor, Type 4 - genetics; Regression analysis; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - metabolism; Tumors; Ki-67; pituitary adenoma; FGFR4 (rs351855 and rs7708357); gene variants; ELISA; p53

To determine the association between FGFR4 (rs351855 and rs7708357) gene variants, serum levels, and immunohistochemical markers (Ki-67 and p53) in pituitary adenoma (PA), a case-control study was conducted involving 300 subjects divided into two groups: the control group (n = 200) and a group of PA...