Alternative promoters and repetitive DNA elements define the species-dependent tissue-specific expression of the FMO1 genes of human and mouse

• Published in: Biochemical journal Vol. 406; no. 3; pp. 491 - 499
• Main Authors: Shephard, Elizabeth A., Chandan, Pritpal, Stevanovic-Walker, Milena, Edwards, Mina, Phillips, Ian R.
• Format: Journal Article
• Language: English
• Published: England Portland Press Ltd 15.09.2007
• Subjects: Alternative Splicing; Animals; Base Sequence; Gene Expression Regulation; Humans; Luciferases - metabolism; Mice; Molecular Sequence Data; Oxygenases - genetics; Oxygenases - metabolism; Promoter Regions, Genetic - genetics; Rabbits; Rats; Regulatory Sequences, Nucleic Acid; Repetitive Sequences, Nucleic Acid; Sequence Homology, Nucleic Acid; Species Specificity; Transcription, Genetic
• ISSN: 0264-6021; 1470-8728; 1470-8728
• DOI: 10.1042/BJ20070523

In humans, expression of the FMO1 (flavin-containing mono-oxygenase 1) gene is silenced postnatally in liver, but not kidney. In adult mouse, however, the gene is active in both tissues. We investigated the basis of this species-dependent tissue-specific transcription of FMO1. Our results indicate t...