Relation among anti-rheumatic drug therapy, CD14+CD16+ blood monocytes and disease activity markers (DAS28 and US7 scores) in rheumatoid arthritis: A pilot study

• Published in: Pharmacological research Vol. 107; pp. 308 - 314
• Main Authors: Amoruso, Angela, Sola, Daniele, Rossi, Luca, Obeng, Joyce Afrakoma, Fresu, Luigia Grazia, Sainaghi, Pier Paolo, Pirisi, Mario, Brunelleschi, Sandra
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.05.2016
• Subjects: Adult; Antibodies - pharmacology; Antibodies - therapeutic use; Antirheumatic Agents - pharmacology; Antirheumatic Agents - therapeutic use; Arthritis, Rheumatoid - drug therapy; Arthritis, Rheumatoid - immunology; Arthritis, Rheumatoid - metabolism; Biological drugs; Biomarkers - metabolism; CD14+CD16+ monocytes; DAS28 score; DMARDs; Female; GPI-Linked Proteins - immunology; Humans; Lipopolysaccharide Receptors - immunology; Male; Methotrexate - pharmacology; Methotrexate - therapeutic use; Middle Aged; Monocytes - drug effects; Monocytes - immunology; Pilot Projects; Prednisone - pharmacology; Prednisone - therapeutic use; Receptors, IgG - immunology; Rheumatoid arthritis; Severity of Illness Index; US7 score; CD14+CD16+ monocytes; Biological drugs; US7 score; DMARDs; DAS28 score; Rheumatoid arthritis; CD14(+)CD16(+) monocytes

[Display omitted] Circulating human monocytes, a functionally and phenotypically heterogeneous population, are emerging as fundamental cell types in rheumatoid arthritis (RA). The aim of this pilot study was to assess the correlation, if any, among anti-rheumatic drug therapy, circulating CD14+CD16+...